Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Jun 1;9(2):39.
doi: 10.3390/medsci9020039.

Hepatocrinology

Affiliations
Review

Hepatocrinology

Sanjay Kalra et al. Med Sci (Basel). .

Abstract

Hepatocrinology is defined as a bidirectional, complex relationship between hepatic physiology and endocrine function, hepatic disease and endocrine dysfunction, hepatotropic drugs and endocrine function, and endocrine drugs and hepatic health. The scope of hepatocrinology includes conditions of varied etiology (metabolic, infectious, autoimmune, and invasive) that we term as hepato-endocrine syndromes. This perspective shares the definition, concept, and scope of hepatocrinology and shares insight related to this aspect of medicine. It is hoped that this communication will encourage further attention and research in this critical field.

Keywords: NAFLD; cirrhosis; diabetes; endocrine; hepatogenous diabetes; liver.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Endocrine manifestations of cirrhosis.

References

    1. Wewer Albrechtsen N.J., Pedersen J., Galsgaard K.D., Winther-Sørensen M., Suppli M.P., Janah L., Gromada J., Vilstrup H., Knop F.K., Holst J.J. The Liver-α-Cell Axis and Type 2 Diabetes. Endocr. Rev. 2019;40:1353–1366. doi: 10.1210/er.2018-00251. - DOI - PubMed
    1. Bach L.A. IGF-binding proteins. J. Mol. Endocrinol. 2018;61:T11–T28. doi: 10.1530/JME-17-0254. - DOI - PubMed
    1. Raghow R. Betatrophin: A liver-derived hormone for the pancreatic β-cell proliferation. World J. Diabetes. 2013;4:234–237. doi: 10.4239/wjd.v4.i6.234. - DOI - PMC - PubMed
    1. Matsusaka T., Niimura F., Shimizu A., Pastan I., Saito A., Kobori H., Nishiyama A., Ichikawa I. Liver Angiotensinogen Is the Primary Source of Renal Angiotensin II. J. Am. Soc. Nephrol. 2012;23:1181–1189. doi: 10.1681/ASN.2011121159. - DOI - PMC - PubMed
    1. Ruchala P., Nemeth E. The pathophysiology and pharmacology of hepcidin. Trends Pharmacol. Sci. 2014;35:155–161. doi: 10.1016/j.tips.2014.01.004. - DOI - PMC - PubMed

Substances