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Review
. 2021 Jun 22;22(13):6667.
doi: 10.3390/ijms22136667.

Endothelial Progenitor Cells Dysfunctions and Cardiometabolic Disorders: From Mechanisms to Therapeutic Approaches

Anne-Christine Peyter  1   2 , Jean-Baptiste Armengaud  2   3 , Estelle Guillot  2   3 , Catherine Yzydorczyk  2   3
Affiliations
Review

Endothelial Progenitor Cells Dysfunctions and Cardiometabolic Disorders: From Mechanisms to Therapeutic Approaches

Anne-Christine Peyter et al. Int J Mol Sci. .

Abstract

Metabolic syndrome (MetS) is a cluster of several disorders, such as hypertension, central obesity, dyslipidemia, hyperglycemia, insulin resistance and non-alcoholic fatty liver disease. Despite health policies based on the promotion of physical exercise, the reduction of calorie intake and the consumption of healthy food, there is still a global rise in the incidence and prevalence of MetS in the world. This phenomenon can partly be explained by the fact that adverse events in the perinatal period can increase the susceptibility to develop cardiometabolic diseases in adulthood. Individuals born after intrauterine growth restriction (IUGR) are particularly at risk of developing cardiovascular diseases (CVD) and metabolic disorders later in life. It has been shown that alterations in the structural and functional integrity of the endothelium can lead to the development of cardiometabolic diseases. The endothelial progenitor cells (EPCs) are circulating components of the endothelium playing a major role in vascular homeostasis. An association has been found between the maintenance of endothelial structure and function by EPCs and their ability to differentiate and repair damaged endothelial tissue. In this narrative review, we explore the alterations of EPCs observed in individuals with cardiometabolic disorders, describe some mechanisms related to such dysfunction and propose some therapeutical approaches to reverse the EPCs dysfunction.

Keywords: cellular senescence; developmental programming; endothelial progenitor cells; intrauterine growth restriction; metabolic syndrome; oxidative stress.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Metabolic syndrome and mechanisms related to EPCs dysfunctions. EPCs: endothelial progenitor cells; NAFLD: non-alcoholic fatty liver disease.
Figure 2
Figure 2
The effects of therapeutical agents on EPCs number and functionality. EPCs: endothelial progenitor cells.
See this image and copyright information in PMC

References

    1. Spahis S., Borys J.M., Levy E. Metabolic Syndrome as a Multifaceted Risk Factor for Oxidative Stress. Antioxid. Redox. Signal. 2017;26:445–461. doi: 10.1089/ars.2016.6756. - DOI - PubMed
    1. Bonomini F., Rodella L.F., Rezzani R. Metabolic syndrome, aging and involvement of oxidative stress. Aging Dis. 2015;6:109–120. doi: 10.14336/AD.2014.0305. - DOI - PMC - PubMed
    1. Grundy S.M., Cleeman J.I., Daniels S.R., Donato K.A., Eckel R.H., Franklin B.A., Gordon D.J., Krauss R.M., Savage P.J., Smith S.C., Jr., et al. Diagnosis and management of the metabolic syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation. 2005;112:2735–2752. doi: 10.1161/CIRCULATIONAHA.105.169404. - DOI - PubMed
    1. Stefan N., Haring H.U., Cusi K. Non-alcoholic fatty liver disease: Causes, diagnosis, cardiometabolic consequences, and treatment strategies. Lancet Diabetes Endocrinol. 2019;7:313–324. doi: 10.1016/S2213-8587(18)30154-2. - DOI - PubMed
    1. Sperling L.S., Mechanick J.I., Neeland I.J., Herrick C.J., Despres J.P., Ndumele C.E., Vijayaraghavan K., Handelsman Y., Puckrein G.A., Araneta M.R., et al. The CardioMetabolic Health Alliance: Working Toward a New Care Model for the Metabolic Syndrome. J. Am. Coll. Cardiol. 2015;66:1050–1067. doi: 10.1016/j.jacc.2015.06.1328. - DOI - PubMed

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