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Review
. 2021 Jun 11;11(6):868.
doi: 10.3390/biom11060868.

Circadian Blood Pressure Rhythm in Cardiovascular and Renal Health and Disease

Jiayang Zhang  1 , Ruoyu Sun  1 , Tingting Jiang  1 , Guangrui Yang  2 , Lihong Chen  1
Affiliations
Review

Circadian Blood Pressure Rhythm in Cardiovascular and Renal Health and Disease

Jiayang Zhang et al. Biomolecules. .

Abstract

Blood pressure (BP) follows a circadian rhythm, it increases on waking in the morning and decreases during sleeping at night. Disruption of the circadian BP rhythm has been reported to be associated with worsened cardiovascular and renal outcomes, however the underlying molecular mechanisms are still not clear. In this review, we briefly summarized the current understanding of the circadian BP regulation and provided therapeutic overview of the relationship between circadian BP rhythm and cardiovascular and renal health and disease.

Keywords: blood pressure; cardiovascular; circadian rhythm; renal.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Molecular mechanism of circadian clock in humans. The molecular oscillator comprises interconnected transcription-translation feedback loops. The expression of CCGs is driven by the output of the molecular clock and adjusts circadian clock of cardiovascular and renal function. ROR activates and REV-ERB represses RORE-mediated transcription. PPARα and PPARγ regulate the expression of BMAL1 and REV-ERB via binding to PPRE in their promoters. As the PPAR partner, RXR inhibits the transcriptional activity of BMAL1-CLOCK complex. RORE, ROR response element. PPRE, PPAR response element. RXR, retinoid X receptor.
See this image and copyright information in PMC

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