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Review
. 2021 Jun 11;26(12):3587.
doi: 10.3390/molecules26123587.

Lipid-Based Nanostructures for the Delivery of Natural Antimicrobials

Cristian Mauricio Barreto Pinilla  1 , Nathalie Almeida Lopes  1 , Adriano Brandelli  1   2
Affiliations
Review

Lipid-Based Nanostructures for the Delivery of Natural Antimicrobials

Cristian Mauricio Barreto Pinilla et al. Molecules. .

Abstract

Encapsulation can be a suitable strategy to protect natural antimicrobial substances against some harsh conditions of processing and storage and to provide efficient formulations for antimicrobial delivery. Lipid-based nanostructures, including liposomes, solid lipid nanoparticles (SLNs), and nanostructured lipid nanocarriers (NLCs), are valuable systems for the delivery and controlled release of natural antimicrobial substances. These nanostructures have been used as carriers for bacteriocins and other antimicrobial peptides, antimicrobial enzymes, essential oils, and antimicrobial phytochemicals. Most studies are conducted with liposomes, although the potential of SLNs and NLCs as antimicrobial nanocarriers is not yet fully established. Some studies reveal that lipid-based formulations can be used for co-encapsulation of natural antimicrobials, improving their potential to control microbial pathogens.

Keywords: liposomes; microbial safety; nanostructures; natural antimicrobials; phospholipids.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic representation and classification of liposomes: (a) hydrophilic molecules encapsulated in water phase of unilamellar vesicle, (b) hydrophobic molecules are including in the phospholipid bilayers of unilamellar vesicle, (c) multilamellar vesicle, and (d) multivesicular vesicle.
Figure 2
Figure 2
Schematic representation of (a) solid lipid nanoparticles (SLNs) and (b) nanostructured lipid carriers (NLCs).
Figure 3
Figure 3
Lipid-based nanocarriers used as delivery systems for natural antimicrobials.
Figure 4
Figure 4
Schematic representation of the antibacterial synergetic effect of free and co-encapsulated antimicrobials.
See this image and copyright information in PMC

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