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Review
. 2021 Jun 16;22(12):6429.
doi: 10.3390/ijms22126429.

Piezo Channels: Awesome Mechanosensitive Structures in Cellular Mechanotransduction and Their Role in Bone

Xia Xu  1   2   3   4 , Shuyu Liu  1   2   3   4 , Hua Liu  1   2   3   4 , Kang Ru  1   2   3   4 , Yunxian Jia  1   2   3   4 , Zixiang Wu  1   2   3   4 , Shujing Liang  1   2   3   4 , Zarnaz Khan  1   2   3   4 , Zhihao Chen  1   2   3   4 , Airong Qian  1   2   3   4 , Lifang Hu  1   2   3   4
Affiliations
Review

Piezo Channels: Awesome Mechanosensitive Structures in Cellular Mechanotransduction and Their Role in Bone

Xia Xu et al. Int J Mol Sci. .

Abstract

Piezo channels are mechanosensitive ion channels located in the cell membrane and function as key cellular mechanotransducers for converting mechanical stimuli into electrochemical signals. Emerged as key molecular detectors of mechanical forces, Piezo channels' functions in bone have attracted more and more attention. Here, we summarize the current knowledge of Piezo channels and review the research advances of Piezo channels' function in bone by highlighting Piezo1's role in bone cells, including osteocyte, bone marrow mesenchymal stem cell (BM-MSC), osteoblast, osteoclast, and chondrocyte. Moreover, the role of Piezo channels in bone diseases is summarized.

Keywords: Piezo channels; bone cells; bone disease; mechanotransduction.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic representation of Piezo1 channel. (a) Lateral view; (b) bottom view; (c) top view. CED: C-terminal extracellular domain; CTD: intracellular C-terminal domain; IH: inner helix; OH: outer helix; PHs: peripheral helices.
See this image and copyright information in PMC

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