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. 2021 Jun 16;26(12):3673.
doi: 10.3390/molecules26123673.

Solvothermal Preparation of a Lanthanide Metal-Organic Framework for Highly Sensitive Discrimination of Nitrofurantoin and l-Tyrosine

Tian-Tian Wang  1 , Jing-Yi Liu  1 , Rui Guo  1 , Jun-Dan An  1 , Jian-Zhong Huo  1 , Yuan-Yuan Liu  1 , Wei Shi  2 , Bin Ding  1
Affiliations

Solvothermal Preparation of a Lanthanide Metal-Organic Framework for Highly Sensitive Discrimination of Nitrofurantoin and l-Tyrosine

Tian-Tian Wang et al. Molecules. .

Abstract

Metal-organic frameworks (MOFs) have been rapidly developed for their broad applications in many different chemistry and materials fields. In this work, a multi-dentate building block 5-(4-(tetrazol-5-yl)phenyl)-isophthalic acid (H3L) containing tetrazole and carbolxylate moieties was employed for the synthesis of a two-dimensional (2D) lanthanide MOF [La(HL)(DMF)2(NO3)] (DMF = N,N-dimethylformamide) (1) under solvothermal condition. The fluorescent sensing application of 1 was investigated. 1 exhibits high sensitivity recognition for antibiotic nitrofurantoin (Ksv: 3.0 × 103 M-1 and detection limit: 17.0 μM) and amino acid l-tyrosine (Ksv: 1.4 × 104 M-1 and detection limit: 3.6 μM). This work provides a feasible detection platform of 2D MOFs for highly sensitive discrimination of antibiotics and amino acids.

Keywords: amino acid; antibiotics; fluorescence; fluorescent probe; metal-organic frameworks.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Scheme 1
Scheme 1
Preparation of the lanthanide metal-organic framework for highly sensitive discrimination of nitrofurantoin and l-tyrosine.
Figure 1
Figure 1
(a) The fundamental structure of 1 (symmetry codes: A 0.5 − x, 1.5 − y, 1 − z; B x,1 − y, 0.5 + z; C x,1 − y, 0.5 + z.); (b) two-dimensional framework of 1.
Figure 2
Figure 2
(a) PXRD patterns of 1; (b) PXRD patterns of 1 soaked in different solutions for 24 h.
Figure 3
Figure 3
(a) The SEM image of 1 at a scale of 20 μm; (b) The SEM image of 1 at a scale of 5 μm.
Figure 4
Figure 4
(a) Photo-luminescent intensities at 353 nm for 1 in the presence of different antibiotics; (b) photo-luminescent intensities at 353 nm for 1 in the presence of different amino acids.
Figure 5
Figure 5
(a) The luminescence spectra of 1 with different concentrations of NFT; (b) The emission spectra by adding different concentration NFT buffer excited at 300 nm; (c) The luminescence spectra of 1 under different concentrations of l-Tyr; (d) The emission spectra by adding different concentration l-Tyr buffer excited at 300 nm.
Figure 6
Figure 6
(a) The decay curve of 1 with the addition of NFT; (b) The decay curve of 1 with the addition of l-Tyr.
Figure 7
Figure 7
Cycling performance of luminescence intensities at 300 nm of 1 for detecting NFT (a) and l-Tyr (b).
Scheme 2
Scheme 2
Synthesis route for 1.
See this image and copyright information in PMC

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