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Review
. 2021 Jun 30;12(7):1006.
doi: 10.3390/genes12071006.

The Genetics of Parkinson's Disease and Implications for Clinical Practice

Jacob Oliver Day  1 , Stephen Mullin  1   2
Affiliations
Review

The Genetics of Parkinson's Disease and Implications for Clinical Practice

Jacob Oliver Day et al. Genes (Basel). .

Abstract

The genetic landscape of Parkinson's disease (PD) is characterised by rare high penetrance pathogenic variants causing familial disease, genetic risk factor variants driving PD risk in a significant minority in PD cases and high frequency, low penetrance variants, which contribute a small increase of the risk of developing sporadic PD. This knowledge has the potential to have a major impact in the clinical care of people with PD. We summarise these genetic influences and discuss the implications for therapeutics and clinical trial design.

Keywords: Parkinson’s disease; clinical trials; genetics; monogenic; polygenic; precision medicine.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Summary of genetic variants in Parkinson’s disease grouped according to allele frequency and associated risk of Parkinson’s disease.
See this image and copyright information in PMC

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