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. 2021 Jul 1;21(1):138.
doi: 10.1186/s12902-021-00800-y.

Interactions between Caveolin-1 (rs3807992) polymorphism and major dietary patterns on cardio-metabolic risk factors among obese and overweight women

Faezeh Abaj  1 , Fariba Koohdani  2 , Masoumeh Rafiee  3 , Ehsan Alvandi  4 , Mir Saeed Yekaninejad  5 , Khadijeh Mirzaei  6
Affiliations

Interactions between Caveolin-1 (rs3807992) polymorphism and major dietary patterns on cardio-metabolic risk factors among obese and overweight women

Faezeh Abaj et al. BMC Endocr Disord. .

Abstract

Background: Caveolin-1 (CAV-1) is a cholesterol-dependent essential component located in caveolae. Several studies have been CAV-1 related to cardio-metabolic parameters in animal models, however, there are few studies in humans. Importantly, there is no study has investigated the interaction between CAV-1 rs3807992 gene and dietary patterns (DPs) on cardio-metabolic risk factors.

Methods: The current cross-sectional study was conducted on 404 overweight and obese women. Dietary intake was obtained from FFQ with 147 items. The CAV-1 genotype was measured by the PCR-RFLP method. The anthropometric measurements, serum lipid profile, and inflammatory markers were measured by standard protocols.

Results: There was a significant interaction between CAV-1 rs3807992 and healthy DP on high-density cholesterol (HDL) (P-interaction = 0.03), TC/HDL (P-interaction = 0.03) and high sensitivity C-reactive protein (hs-CRP) (P-interaction = 0.04); in A-allele carriers, higher following a healthy DP was related to a higher level of HDL and lower TC/HDL and hs-CRP. As well as, the significant interactions were observed between CAV-1 rs3807992 and unhealthy DP in relation to triglyceride (TG) (P-interaction = 0.001), aspartate aminotransferase (AST) (P-interaction = 0.01) and monocyte chemoattractant protein-1(MCP-1) (P-interaction = 0.01); A-allele carriers were more following the unhealthy DP had lower levels of TG, AST and MCP-1.

Conclusions: Our study revealed a significant gene-diet interaction between rs3807992 SNPs and DPs in relation to cardio-metabolic risk factors; A-allele carriers might be more sensitive to dietary composition compared to GG homozygotes. Following a healthy DP in A-allele-carriers may be improved their genetic association with cardio-metabolic risk factors.

Keywords: Cardio-metabolic; Caveolin-1; Diet; Gene-environment interaction; Personalized diet; Polymorphism.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
The interaction between Cav-1 SNP rs807992 and healthy dietary pattern on; (a) HDL, (b) TC, (c) hs-Crp, (d) MCP-1, (e) TC/HDL (f) LDL/HDL
Fig. 2
Fig. 2
The interaction between Cav-1 SNP rs807992 and Unhealthy dietary pattern on; (a) TG, (b) AST, (c) MCP-1, (d) LDL/HDL, (e) PAI-1and (f) LDL
See this image and copyright information in PMC

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