Correction to: Pyroptosis: a new paradigm of cell death for fighting against cancer

Yixin Tan^{1

2

3

4}, Quanzhu Chen^{1

2

3}, Xiaoling Li^{1

2

3}, Zhaoyang Zeng^{1

2

3}, Wei Xiong^{1

2

3}, Guiyuan Li^{1

2

3}, Xiayu Li³, Jianbo Yang⁵, Bo Xiang^{6

7

8}, Mei Yi^{9

10

11}

Affiliations

¹ NHC Key Laboratory of Carcinogenesis, Hunan Provincial Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Tongzipo Road, Changsha, 410013, Hunan, China.
² The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute and School of Basic Medical Sciences, Central South University, Changsha, 410078, Hunan, China.
³ Hunan Key Laboratory of Nonresolving Inflammation and Cancer, The Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.
⁴ Department of Dermatology, The Second Xiangya Hospital, The Central South University, Changsha, 410011, Hunan, China.
⁵ Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, 55455, USA.
⁶ NHC Key Laboratory of Carcinogenesis, Hunan Provincial Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Tongzipo Road, Changsha, 410013, Hunan, China. xiangbolin@csu.edu.cn.
⁷ The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute and School of Basic Medical Sciences, Central South University, Changsha, 410078, Hunan, China. xiangbolin@csu.edu.cn.
⁸ Hunan Key Laboratory of Nonresolving Inflammation and Cancer, The Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China. xiangbolin@csu.edu.cn.
⁹ NHC Key Laboratory of Carcinogenesis, Hunan Provincial Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Tongzipo Road, Changsha, 410013, Hunan, China. yi_mei@csu.edu.cn.
¹⁰ The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute and School of Basic Medical Sciences, Central South University, Changsha, 410078, Hunan, China. yi_mei@csu.edu.cn.
¹¹ Department of Dermatology, Xiangya Hospital, The Central South University, Changsha, 410008, Hunan, China. yi_mei@csu.edu.cn.

PMID: 34210329
PMCID: PMC8247097
DOI: 10.1186/s13046-021-02020-7

Published Erratum

Correction to: Pyroptosis: a new paradigm of cell death for fighting against cancer

Yixin Tan et al. J Exp Clin Cancer Res. 2021.

. 2021 Jul 1;40(1):219.

doi: 10.1186/s13046-021-02020-7.

Authors

Affiliations

¹ NHC Key Laboratory of Carcinogenesis, Hunan Provincial Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Tongzipo Road, Changsha, 410013, Hunan, China.
² The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute and School of Basic Medical Sciences, Central South University, Changsha, 410078, Hunan, China.
³ Hunan Key Laboratory of Nonresolving Inflammation and Cancer, The Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.
⁴ Department of Dermatology, The Second Xiangya Hospital, The Central South University, Changsha, 410011, Hunan, China.
⁵ Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, 55455, USA.
⁶ NHC Key Laboratory of Carcinogenesis, Hunan Provincial Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Tongzipo Road, Changsha, 410013, Hunan, China. xiangbolin@csu.edu.cn.
⁷ The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute and School of Basic Medical Sciences, Central South University, Changsha, 410078, Hunan, China. xiangbolin@csu.edu.cn.
⁸ Hunan Key Laboratory of Nonresolving Inflammation and Cancer, The Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China. xiangbolin@csu.edu.cn.
⁹ NHC Key Laboratory of Carcinogenesis, Hunan Provincial Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Tongzipo Road, Changsha, 410013, Hunan, China. yi_mei@csu.edu.cn.
¹⁰ The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute and School of Basic Medical Sciences, Central South University, Changsha, 410078, Hunan, China. yi_mei@csu.edu.cn.
¹¹ Department of Dermatology, Xiangya Hospital, The Central South University, Changsha, 410008, Hunan, China. yi_mei@csu.edu.cn.

PMID: 34210329
PMCID: PMC8247097
DOI: 10.1186/s13046-021-02020-7

No abstract available

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Figures

**Fig. 1**
The canonical inflammasome and non-canonical inflammasome pathway in pyroptosis. The canonical inflammasome is assembled in response to exogenous pathogens and endogenous damage by intracellular sensor proteins, including NLRP1b, NLRC4, NLRP3, AIM2 and Pyrin. The canonical inflammasomes recruit pro-caspase 1 through inflammasome adaptor protein ASC, leading self-cleavage and activation of caspase 1. Active caspase 1 cleaves pro-inflammatory cytokines pro-IL-1β, pro-IL-18, leading to maturation of IL-1β, IL-18. Active caspase 1 cleaves GSDMD protein at the middle linker, liberating the cytotoxic N-terminus to form pore on plasma membrane, which allows the release of mature IL-1β, IL-18. In non-canonical pathway, LPS directly binds to murine pro-caspase 11 or its human homologs pro-caspase 4 and 5, leading activation of caspase 11/4/5. In non-canonical inflammasome pathway, cleavage of GSDMD is executed by active caspase 11 or caspase 4 and 5 upon direct binding of cytosolic LPS. Chemotherapy drugs could induce pyroptosis in epithelial cells through activating mitochondrial death machinery and caspase 3. In this case, GSDME is cleaved by active caspase 3. GSDME-N in turn activates NLRP3 inflammasome, leading to activation of caspase 1/GSDMD cascade, which promotes maturation of IL-1β, IL-18. Gasdermins could be cleaved by Lymphocyte-derived granzymes proteases, unleashing the pore-formation ability to trigger pyroptosis of cancer cells

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Erratum for

Pyroptosis: a new paradigm of cell death for fighting against cancer.
Tan Y, Chen Q, Li X, Zeng Z, Xiong W, Li G, Li X, Yang J, Xiang B, Yi M. Tan Y, et al. J Exp Clin Cancer Res. 2021 May 3;40(1):153. doi: 10.1186/s13046-021-01959-x. J Exp Clin Cancer Res. 2021. PMID: 33941231 Free PMC article. Review.

References

1. Tan Y, Chen Q, Li X, Zeng Z, Xiong W, Li G, Li X, Yang J, Xiang B, Yi M. Pyroptosis: a new paradigm of cell death for fighting against cancer. J Exp Clin Cancer Res. 2021;40:153. doi: 10.1186/s13046-021-01959-x. - DOI - PMC - PubMed

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Correction to: Pyroptosis: a new paradigm of cell death for fighting against cancer

Affiliations

Correction to: Pyroptosis: a new paradigm of cell death for fighting against cancer

Authors

Affiliations

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