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Review
. 2021 Aug;48(3):283-296.
doi: 10.1016/j.ucl.2021.03.001. Epub 2021 Jun 12.

Prostate Cancer Predisposition

Yasin Bhanji  1 , William B Isaacs  2 , Jianfeng Xu  3 , Kathleen A Cooney  4
Affiliations
Review

Prostate Cancer Predisposition

Yasin Bhanji et al. Urol Clin North Am. 2021 Aug.

Abstract

The identification and characterization of alterations in prostate cancer (PCa)-predisposing genes can help to inform screening strategies in undiagnosed men and treatment options in men in both the clinically localized and in the metastatic setting. This review provides an overview of the genetic basis underlying hereditary predisposition to PCa, the current role of genetics and PCa risk assessment, and how genetic risk factors affect aggressiveness and lethality of PCa.

Keywords: Cancer susceptibility gene; Hereditary cancer syndrome; Polygenic risk score; Prostate cancer.

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Conflict of interest statement

Disclosure The generous support from the Patrick C Walsh Hereditary Prostate Cancer program is gratefully acknowledged. This study was supported by grants from Department of Defense (W81XWH-16-1-0764, W81XWH-16-1-0765, and W81XWH-16-1-0766).

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