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. 1978 Jan 31;186(3):393-8.
doi: 10.1007/BF00224929.

beta-Lipotropin in brain: localization in hypothalamic neurons by immunoperoxidase technique

E A Zimmerman, A Liotta, D T Krieger

beta-Lipotropin in brain: localization in hypothalamic neurons by immunoperoxidase technique

E A Zimmerman et al. Cell Tissue Res. .

Abstract

beta-Lipotropin (beta-LPH) has been localized in hypothalamus and pituitary of sheep and ox by the immunoperoxidase technique. In both species beta-LPH was found in perikarya of arcuate neurons as well as in cells of the anterior and intermediate lobes of the pituitary. A large number of immunoreactive axons were found in the arcuate region; some appeared to innervate other neurons and others projected to portal capillaries. Stained fiber segments were also scattered throughout the hypothalamus. The presence of beta-LPH in hypothalamic neurons supports the possibility that brain beta-LPH may be a precursor for opiate-like or other peptides which may be involved in neuromodulation or neurohormonal activities.

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