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Comment
. 2021 Jul 2;373(6550):24-25.
doi: 10.1126/science.abj5072.

An anti-obesity immunotherapy?

Conan J O O'Brien  1 , Ana I Domingos  2
Affiliations
Comment

An anti-obesity immunotherapy?

Conan J O O'Brien et al. Science. .
No abstract available

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Figures

None
Resident adipose tissue macrophages (RATMs) control lipid storage via production of PDGFcc.
In early life and in response to over nourishment, RATMs (green cells) upregulate PDGFcc production which induces lipid retention in white adipose tissue adipocytes in a paracrine manner, though the precise mechanism remains unclear. This action of RATMs is distinct from their recruited CCR2-dependent counterparts. These macrophages (red cells) are responsible for the pro-inflammatory cytokine expression that characterises obese adipose tissue. Treatment with anti-PDGFcc antibodies results in the restoration of homeostasis, with reduced lipid storage, smaller adipocyte size, and a reduction in body weight which is independent of food intake. Excess lipids are redirected towards the liver and towards thermogenesis in brown adipose tissue.
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References

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