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. 2021 Oct;36(5):1088-1092.
doi: 10.1007/s12250-021-00411-w. Epub 2021 Jul 1.

Profiles of SARS-CoV-2 RNA and Antibodies in Inpatients with COVID-19 not Related with Clinical Manifestation: A Single Centre Study

Li Zhao  1 , Ruqin Gao  2 , Roujian Lu  1 , Huijuan Wang  1 , Yao Deng  1 , Peihua Niu  1 , Fachun Jiang  2 , Baoying Huang  1 , Jiwei Liang  2 , Jing Jia  2 , Feng Zhang  2 , Wenling Wang  3 , Guizhen Wu  4   5 , Wenjie Tan  6   7
Affiliations

Profiles of SARS-CoV-2 RNA and Antibodies in Inpatients with COVID-19 not Related with Clinical Manifestation: A Single Centre Study

Li Zhao et al. Virol Sin. 2021 Oct.
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Detection of viral RNA and antibodies in samples of COVID-19 patients. A Comparison of viral RNA loads in COVID-19 patients detected by nasopharyngeal swab, sputum, and faecal samples (left) Viral RNA loads in COVID-19 patients with different clinical manifestations. B Serum IgM and IgG profiles in COVID-19 patients as analysed using RBD-based enzyme-linked immunosorbent assay (ELISA). a–c Cross-sectional profiles of absorbance at 450 nm (OD450nm) by IgM (a) and IgG (b) against RBD and by neutralising antibody (NAb) in a pseudovirus particle neutralisation test (c). Each dot represents an individual serum sample. d, Comparison of IgM, IgG, and NAb. e, Chronological changes (weeks after symptom onset) in IgM and IgG titres based on RBD-ELISA, and in NAb titres. f and g Changes in IgM (f) and IgG (g) levels between matched pairs of serum samples from COVID-19 patients. Each line represents an individual patient. C Detection of viral RNA and antibodies in SARS-CoV-2-infected patients. Results of matched-pair analysis to detect RNA (left) and antibody levels (right) in SARS-CoV-2-infected individuals. Classification: 1 indicated as asymptomatic patients, 2 indicated as mild patients, 3 indicated as moderate patients, 4 indicated as severe patients. *P < 0.05, **P < 0.01, ***P < 0.001.
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