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. 2021 Dec;57(12):1960-1965.
doi: 10.1111/jpc.15628. Epub 2021 Jul 2.

Efficacy of topical steroid treatment in children with severe phimosis in China: A long-term single centre prospective study

Guanglun Zhou  1 , Man Jiang  2 , Zhilin Yang  1 , Wanhua Xu  1 , Shoulin Li  1
Affiliations

Efficacy of topical steroid treatment in children with severe phimosis in China: A long-term single centre prospective study

Guanglun Zhou et al. J Paediatr Child Health. 2021 Dec.

Abstract

Aim: To evaluate the efficacy of topical steroid (0.1% mometasone furoate) therapy and factors affecting long-term outcome of paediatric severe phimosis in China.

Methods: A total of 1550 patients with severe phimosis classified by Kikiros system were prospectively enrolled in the study from January 2016 to February 2020. They were prescribed with 0.1% mometasone furoate twice a day for 4 weeks. Patients were re-evaluated at the end of weeks 2, 4, 8 and 6 months follow-up.

Results: A total of 1499 patients completed the treatment, 71.1% responded at the end of week 4. The long-term success rate was 66.0% over a mean follow-up of 26.9 months. The success rate of grade 4 phimosis was significantly higher than that of grade 5 at 4, 8 weeks and 6 months (P = 0.005, P < 0.001 and P < 0.001, respectively). Patients with balanoposthitis had a poorer outcome compared with patients without symptoms and patients symptoms by prepuce ballooning or urinary tract infections (P < 0.001). Initial grade of 5 phimosis and symptom with balanoposthitis were independent risk factors for recurrence. All patients had no systemic side effects, 23 cases developed local erythema or burning sensation.

Conclusion: Topical steroid (0.1% mometasone furoate) is an effective treatment for severe phimosis in children. The recurrence was related to the grade or symptoms of severe phimosis.

Keywords: children; mometasone furoate; phimosis; steroid.

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Figures

Fig. 1
Fig. 1
Our patients with the grade of phimosis was assessed by Kikiros and Woodward: (a) grade 5 of phimosis; (b) grade 4 of phimosis; (c) grade 3 of phimosis; (d) grade 2 of phimosis; and (e) grade 0 or 1 of phimosis.
See this image and copyright information in PMC

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