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Case Reports
. 2021 Jul 1;92(3):e2021207.
doi: 10.23750/abm.v92i3.11592.

Abnormal Levels of Pepsinogen I and Gastrin 17 in a case of Ménétrier Disease

Pellegrino Crafa  1 , Marilisa Franceschi  2 , Lorella Franzoni  3 , Francesco Di Mario  4
Affiliations
Case Reports

Abnormal Levels of Pepsinogen I and Gastrin 17 in a case of Ménétrier Disease

Pellegrino Crafa et al. Acta Biomed. .

Abstract

Background and aim: We describe a case of Ménétrier disease, occurred in female patient.

Methods: We decide to assess by non-invasive way (serum pepsinogens and gastrin 17) the secretory status of gastric mucosa, to confirm previous data of the literature, claiming high levels of both acid secretion and hypergastrinemia in this rare pathological condition.

Results and conclusion: We find in the subject the highest values of pepsinogen 1 - a marker of acid secretion - never described in the literature to our knowledge: 1940 mcg/L, being normal values ranging from 30-160 mcg/L. Similarly, gastrin 17, produced 90% in the antrum and responsible for negative acid feedback, was very high: 139 pg/L, ranging normal values between 1-10 pg/L. (www.actabiomedica.it).

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Conflict of interest statement

Each author declares no conflict of interest and that he or she has no commercial associations (e.g. consultancies, stock ownership, equity interest, patent/licensing arrangement etc.) that might pose a conflict of interest in connection with the submitted article

Figures

Fig. 1:
Fig. 1:
Hematoxylin-eosin, 20x. Hyperplastic gastric plica with hyperplasia of mucous cells delineating tortuous and cistically dilated foveolar glands in the gastric body. Loss of parietal cells and edema of the lamina propria.
Fig. 2:
Fig. 2:
Immunoistochemical staining for Ki-67, 4x: Increased proliferative activity in the adenoma portion, with minimal activity in the adjacent foveolar epithelium.
See this image and copyright information in PMC

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