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Editorial
. 2021 Jun 29;31(6):664-666.
doi: 10.1093/glycob/cwab045.

Microbial transformation of the host glycobiome

Christine M Szymanski  1 , Nicole M Koropatkin  2
Affiliations
Editorial

Microbial transformation of the host glycobiome

Christine M Szymanski et al. Glycobiology. .
No abstract available

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Figures

Fig. 1
Fig. 1
Remodeling of host glycoproteins intensifies sepsis. Gram negative pathogens such as Salmonella species and Escherichia coli stimulate TLR4 to increase production of host neuraminidases, which leads to enhanced clearance of alkaline phosphatase isozymes TNAP and IAP by the Ashwell-Morell receptor. Loss of alkaline phosphatase, which can detoxify LPS, perpetuates inflammation and reduces survival in a murine sepsis model. Reprinted with permission from Yang et al. (2018).
See this image and copyright information in PMC

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