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Review
. 2021 Aug;47(3):317-333.
doi: 10.1016/j.rdc.2021.04.002. Epub 2021 Jun 9.

Neutrophil Dysregulation in the Pathogenesis of Systemic Lupus Erythematosus

Yudong Liu  1 , Mariana J Kaplan  2
Affiliations
Review

Neutrophil Dysregulation in the Pathogenesis of Systemic Lupus Erythematosus

Yudong Liu et al. Rheum Dis Clin North Am. 2021 Aug.

Abstract

The recent identifications of a subset of proinflammatory neutrophils, low-density granulocytes, and their ability to readily form neutrophil extracellular traps led to a resurgence of interest in neutrophil dysregulation in the pathogenesis of systemic lupus erythematosus (SLE). This article presents an overview on how neutrophil dysregulation modulates the innate and adaptive immune responses in SLE and their putative roles in disease pathogenesis. The therapeutic potential of targeting this pathogenic process in the treatment of SLE is also discussed.

Keywords: Immune dysregulation; Low-density granulocytes; Neutrophils; Organ damage; Systemic lupus erythematosus; Type I interferons.

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Conflict of interest statement

Disclosure The authors have nothing to disclose.

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