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Comment
. 2021 Aug;42(8):617-619.
doi: 10.1016/j.tips.2021.06.003. Epub 2021 Jun 29.

Teaching an old dog new tricks: repurposing β-lactams

Vega Miguel-Ruano  1 , Juan A Hermoso  2
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Teaching an old dog new tricks: repurposing β-lactams

Vega Miguel-Ruano et al. Trends Pharmacol Sci. 2021 Aug.

Abstract

Recently, Martelli and colleagues reported on the structural and functional characterization of new antimycobacterials based on N-thio-β-lactams. Surprisingly, the inhibitory mechanism follows a path unexpected for β-lactams, providing an alternative route to defeat drug-resistant strains of Mycobacterium tuberculosis.

Keywords: Mycobacterium tuberculosis; antibiotics; mechanism of action; structural biology; β-lactams.

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