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Case Reports
. 2021 Sep:110:229-231.
doi: 10.1016/j.ijid.2021.06.054. Epub 2021 Jun 30.

Interferon-gamma release assay testing to assess COVID-19 vaccination response in a SARS-CoV-2 seronegative patient on rituximab: a case report

Jessica Ferguson  1 , Kanagavel Murugesan  2 , Niaz Banaei  3 , Anne Liu  4
Affiliations
Case Reports

Interferon-gamma release assay testing to assess COVID-19 vaccination response in a SARS-CoV-2 seronegative patient on rituximab: a case report

Jessica Ferguson et al. Int J Infect Dis. 2021 Sep.

Abstract

We describe the case of a 44-year-old female patient on rituximab for the treatment of multiple sclerosis with undetectable severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgG specific antibodies 18 days after the second dose of SARS-CoV-2 vaccine. Interferon-gamma release assay testing for SARS-CoV-2 was positive on day 19, demonstrating a robust T cell-mediated response despite the lack of an antibody-mediated response.

Keywords: Impaired humoral immunity; SARS-CoV-2; SARS-CoV-2 vaccination; T cell respone.

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Conflict of interest statement

Conflict of interest All authors have no conflict of interest to report.

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