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. 2021 Sep 15:48:128237.
doi: 10.1016/j.bmcl.2021.128237. Epub 2021 Jul 1.

Angucyclines containing β-ᴅ-glucuronic acid from Streptomyces sp. KCB15JA151

Gil Soo Kim  1 , Jun-Pil Jang  2 , Tae Hoon Oh  3 , Mincheol Kwon  1 , Byeongsan Lee  3 , Jung-Sook Lee  4 , Sung-Kyun Ko  2 , Young-Soo Hong  1 , Jong Seog Ahn  5 , Jae-Hyuk Jang  6
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Free article

Angucyclines containing β-ᴅ-glucuronic acid from Streptomyces sp. KCB15JA151

Gil Soo Kim et al. Bioorg Med Chem Lett. .
Free article

Abstract

Two angucyclines, pseudonocardones D (1) and E (2), were isolated from Streptomyces sp. KCB15JA151. The planar structure was elucidated by comprehensive spectroscopic analysis. The absolute configuration of the sugar unit was determined based on the basis of coupling constants, ROESY, chemical derivatization and HPLC analysis. The biological activities of compounds 1 and 2 were examined by performing a computational target prediction, which led to tests of the antiestrogenic activity. The result suggested that compound 1 might be an ERα antagonist.

Keywords: Angucycline; Streptomyces sp.; β-ᴅ-Glucuronic acid.

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