Abstract

PIP: A review of the nature of estrogens (Es) and their effects on the female genital tract, the effects of deprivation in the climacteric, and treatment of menopausal women is presented. The production of E begins in significant amounts in puberty. It is necessary for growth and development, secondary sex characteristics, and maintenance of pregnancy. Specific structural and metabolic alterations produced by E deficiency are described. Symptoms of the climacteric and postmenopause vary widely in severity. Familial, cultural,and educational background are important aspects of symptom development as is the psychological status of the woman. The role of E in the etiology of endometrial cancer is still unclear although some relationship is suggested. A description of therapy includes dose and administration and surveillance. There must be positive indication for the use of E and constant follow-up must be included.