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Review
. 2021 Sep;10(9):973-982.
doi: 10.1002/psp4.12681. Epub 2021 Aug 1.

Anti-SARS-CoV-2 Repurposing Drug Database: Clinical Pharmacology Considerations

Xinyuan Zhang  1 , Yuching Yang  1 , Manuela Grimstein  1 , Guansheng Liu  1 , Eliford Kitabi  1 , Jianghong Fan  1 , Ying-Hong Wang  1 , Justin Earp  1 , James L Weaver  1 , Hao Zhu  1 , Jiang Liu  1 , Kellie S Reynolds  1 , Shiew-Mei Huang  1 , Yaning Wang  1
Affiliations
Review

Anti-SARS-CoV-2 Repurposing Drug Database: Clinical Pharmacology Considerations

Xinyuan Zhang et al. CPT Pharmacometrics Syst Pharmacol. 2021 Sep.

Abstract

A critical step to evaluate the potential in vivo antiviral activity of a drug is to connect the in vivo exposure to its in vitro antiviral activity. The Anti-SARS-CoV-2 Repurposing Drug Database is a database that includes both in vitro anti-SARS-CoV-2 activity and in vivo pharmacokinetic data to facilitate the extrapolation from in vitro antiviral activity to potential in vivo antiviral activity for a large set of drugs/compounds. In addition to serving as a data source for in vitro anti-SARS-CoV-2 activity and in vivo pharmacokinetic information, the database is also a calculation tool that can be used to compare the in vitro antiviral activity with in vivo drug exposure to identify potential anti-SARS-CoV-2 drugs. Continuous development and expansion are feasible with the public availability of this database.

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Conflict of interest statement

The authors declared no competing interests for this work.

Figures

FIGURE 1
FIGURE 1
Illustration of database construction and utility. ADME, absorption, distribution, metabolism, and excretion; CC50, the drug concentration that reduces the total cell number by 50% values; EC50, the drug concentration that inhibits 50% of the virus; EC90, the drug concentration that inhibits 90% of the virus; fup, unbound fraction in plasma; MW, molecular weight; PK, pharmacokinetic
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