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. 2021 Sep;127(3):e111-e113.
doi: 10.1016/j.bja.2021.06.002. Epub 2021 Jun 8.

Improved oxygenation with inhaled milrinone in mechanically ventilated patients with severe COVID-19

Dominik J Vogel  1 , Aimee Brame  2 , Fraser Hanks  3 , Chris Remmington  3 , Natali Chung  4 , Luigi Camporota  5
Affiliations

Improved oxygenation with inhaled milrinone in mechanically ventilated patients with severe COVID-19

Dominik J Vogel et al. Br J Anaesth. 2021 Sep.
No abstract available

Keywords: COVID-19; acute respiratory distress syndrome; hypoxaemia; milrinone; phosphodiesterase 3 inhibitor; pulmonary vasodilator.

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Figures

Fig 1
Fig 1
Box and whisker plot of indices of oxygenation: (a) Oxygenation Index OI=meanairwaypressure(cmH2O)×FiO2×100/Pao2(mmHg) and (b) Pao2/FiO2 ratio (kPa). Lower OI reflects improved arterial oxygenation, or similar oxygenation for lower applied mean airway pressure or FiO2. There was a significant main effect of inhaled milrinone on Pao2/FiO2 ratio (P<0.01) and OI (P<0.001), comparing all obtained values until and including the post-12 h dose (n=14 for each time point). The ends of the whiskers are set at 1.5× inter-quartile range above the third quartile and below the first quartile, or the minimum or maximum value if within these limits. All values are shown as circles.
See this image and copyright information in PMC

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