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Comparative Study
. 2021 Apr;75(2):112-115.
doi: 10.5455/medarh.2021.75.112-115.

Antimicrobial Resistance and the Successful Eradication of Helicobacter pylori-Induced Gastroduodenal Ulcers in Vietnamese Children

Ha Van Thieu  1   2 , Nguyen Minh Duc  3   4 , Bui Thi Dung Nghi  1 , Ngo Van Bach  1 , Ha Huy Khoi  1 , Vo Ngoc Thuy Tien  1 , Mai Tan Lien Bang  3 , Tang Le Chau Ngoc  2
Affiliations
Comparative Study

Antimicrobial Resistance and the Successful Eradication of Helicobacter pylori-Induced Gastroduodenal Ulcers in Vietnamese Children

Ha Van Thieu et al. Med Arch. 2021 Apr.

Abstract

Background: Helicobacter pylori infections induce chronic gastric mucosal inflammation and peptic ulcer disease, and eradication is recommended.

Objective: To investigate antibiotic resistance and H. pylori eradication rates in children with gastroduodenal ulcers in Vietnam.

Methods: We performed gastroduodenal endoscopies, H. pylori cultures, and antimicrobial susceptibility testing (clarithromycin, amoxicillin, metronidazole, tetracycline, and levofloxacin) In children with gastroduodenal ulcers at Children's Hospital 2 from November 1, 2019, to June 30, 2020.

Results: A total of 76 participants were studied, with an average age of 9.3 ± 2.8 years (range: 4-15 years), including 52.6% males and 47.4% females. The antibiotic resistance rates were clarithromycin, 92.1%; amoxicillin, 50%; levofloxacin, 31.6%; metronidazole, 14.5%; and tetracycline, 0%. The successful eradication rate was 44.7%. Bismuth increased the eradication rate by 3.69-fold that without bismuth (p = 0.030). The eradication rate of levofloxacin was high (100%, p = 0.038) compared with other antibiotics. The effectiveness of high-dose amoxicillin in cases with >50% H. pylori amoxicillin resistance was only 32.6% (p = 0.015).

Conclusion: Increased antibiotic resistance among H. pylori resulted in decreased eradication efficacy, which was 44.7% in this study. Drug combinations, such as levofloxacin and bismuth, can increase the H. pylori eradication efficacy in children.

Keywords: Children; Helicobacter pylori; eradication rate; resistance.

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Conflict of interest statement

There are no conflicts of interest to declare.

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