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Review
. 2021;27(4):368-371.
doi: 10.1007/s12268-021-1595-3. Epub 2021 Jun 26.

SARS-CoV-2 Nsp1: Ein kleines Protein blockiert die Immunantwort

[Article in German]
Konstantin Sparrer  1 , Frank Kirchhoff  1
Affiliations
Review

SARS-CoV-2 Nsp1: Ein kleines Protein blockiert die Immunantwort

[Article in German]
Konstantin Sparrer et al. Biospektrum (Heidelb). 2021.

Abstract

The Coronavirus disease 2019 (COVID-19) pandemic is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To facilitate its own replication and avoid immune control, SARS-CoV-2 manipulates its target cells. Our results revealed that the SARS-CoV-2 non-structural protein 1 (Nsp1) plays a key role in viral immune evasion. It blocks the mRNA tunnel of the cellular ribosome, resulting in a shutdown of translation and strong attenuation of the host's antiviral immune response.

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References

    1. Dong E, Du H, Gardner L. An interactive web-based dashboard to track COVID-19 in real time. Lancet Infect Dis. 2020;20:533–534. doi: 10.1016/S1473-3099(20)30120-1. - DOI - PMC - PubMed
    1. Andersen KG, Rambaut A, Lipkin WI, et al. The proximal origin of SARS-CoV-2. Nat Med. 2020;26:450–452. doi: 10.1038/s41591-020-0820-9. - DOI - PMC - PubMed
    1. CDC (2020) Evidence used to update the list of underlying medical conditions that increase a person’s risk of severe illness from COVID-19. https://www.cdc.gov/coronavirus/2019-ncov/need-extra-precautions/evidenc... - PubMed
    1. Müller JA, Groß R, Conzelmann C, et al. SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas. Nat Metab. 2021;3:149–165. doi: 10.1038/s42255-021-00347-1. - DOI - PubMed
    1. Sparrer KMJ, Gack MU. Intracellular detection of viral nucleic acids. Curr Opin Microbiol. 2015;26:1–9. doi: 10.1016/j.mib.2015.03.001. - DOI - PMC - PubMed

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