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Review
. 2021;27(4):376-379.
doi: 10.1007/s12268-021-1587-3. Epub 2021 Jun 26.

Atlas der SARS-CoV-2-RNA-Protein-Interaktionen in infizierten Zellen

[Article in German]
Nora Schmidt  1 , Mathias Munschauer  1   2
Affiliations
Review

Atlas der SARS-CoV-2-RNA-Protein-Interaktionen in infizierten Zellen

[Article in German]
Nora Schmidt et al. Biospektrum (Heidelb). 2021.

Abstract

Using RNA antisense purification and mass spectrometry, we identified more than 100 human proteins that directly and specifically bind SARS-CoV-2 RNA in infected cells. To gain insights into the functions of selected RNA interactors, we applied genetic perturbation and pharmacological inhibition experiments, and mapped the contact sites on the viral RNA. This led to the identification of host dependency factors and defense strategies, which can guide the design of novel therapeutics against SARS-CoV-2.

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