Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Mar-Apr;24(2):269-272.
doi: 10.4103/aian.AIAN_304_20. Epub 2021 Jan 8.

Neurolymphomatosis as a Presenting Feature of Primary Testicular Lymphoma

Affiliations

Neurolymphomatosis as a Presenting Feature of Primary Testicular Lymphoma

Tushar P Raut et al. Ann Indian Acad Neurol. 2021 Mar-Apr.
No abstract available

PubMed Disclaimer

Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
(a) 3D T1 postgadolinium contrast Magnetic resonance imaging MRI Axial sequence revealing enhancement of bilateral seventh and eight nerve complex (arrow heads). (b) Enhancement of bilateral oculomotor nerve roots after exiting from midbrain. (c) T1 Fat suppression Postcontrast MRI of Lumbosacral spine sagittal view showing epidural enhancement and subtle enhancement of cauda equine nerve roots (yellow arrows)
Figure 2
Figure 2
(a) CSF Cytospin smear microphotograph showing large atypical cells with interspersed lymphocytes. (b) H and E Staining showing sheets of atypical lymphoid cells. (c) Immunohistochemistry IHC Showing strong membranous diffuse expression of CD 20
Figure 3
Figure 3
(a-d): CSF Flowcytometry scatter plot showing Abnormal B cells large in size and showing high side scatter along with CD45, CD19, and CD20 expression and lambda light chain clonality
Figure 4
Figure 4
(a) PET CT Showing Increased uptake in left retroperitoneal lymph nodes. (b) Follow up PET CT Showing complete resolution of metabolic activity in previously seen lymph nodes. (c) PET CT Showing increased metabolic activity in left testis and hydrocele. (d) Follow-up PET CT Showing complete resolution of metabolic activity and hydrocele

References

    1. Baehring JM, Damek D, Martin EC, Betensky RA, Hochberg FH. Neurolymphomatosis. Neuro Oncol. 2003;5:104–15. - PMC - PubMed
    1. Grisariu S, Avni B, Batchelor TT, van den Bent MJ, Bokstein F, Schiff D, et al. International Primary CNS Lymphoma Collaborative Group. Neurolymphomatosis: An International Primary CNS Lymphoma Collaborative Group report. Blood. 2010;115:5005–11. - PMC - PubMed
    1. Sunami Y, Gotoh A, Hamano Y, Yahata Y, Sakurai H, Shirane S, et al. Various neurological symptoms by neurolymphomatosis as the initial presentation of primary testicular lymphoma. Case Rep Oncol. 2015;8:200–4. - PMC - PubMed
    1. Gan HK, Azad A, Cher L, Mitchell PL. Neurolymphomatosis: Diagnosis, management, and outcomes in patients treated with rituximab. Neuro Oncol. 2010;12:212–5. - PMC - PubMed
    1. Paes FM, Kalkanis DG, Sideras PA, Serafini AN. FDG PET/CT of extranodal involvement in non-Hodgkin lymphoma and Hodgkin disease. Radiographics. 2010;30:269–91. - PubMed