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. 2021 Apr-Jun;12(2):143-149.
doi: 10.4103/ccd.ccd_342_20. Epub 2021 Jun 14.

Allogeneic Bone Application in Association with Platelet-Rich Plasma for Alveolar Bone Grafting of Cleft Palate Defects

Cimara Fortes Ferreira  1 , João Luiz Carlini  2 , Ricardo de Souza Magini  3 , José Nazareno Gil  4 , André Luis Zétola  5
Affiliations

Allogeneic Bone Application in Association with Platelet-Rich Plasma for Alveolar Bone Grafting of Cleft Palate Defects

Cimara Fortes Ferreira et al. Contemp Clin Dent. 2021 Apr-Jun.

Abstract

Aim: The aim of this study is to compare allogeneic bone grafts associated with platelet-rich plasma (ALBGs-PRP) to autogenous bone grafts (ATBGs) for alveolar reconstructions in patients with cleft lip and palate (CLP).

Materials and methods: The Maxillofacial Surgery Service of the Comprehensive Care Center for CLP (CCCLP) in Curitiba (Paraná, Brazil).

Patients: Thirty out of 46 patients with 8-12 years of age and pre- or trans-foramen unilateral clefts were operated by the same surgeon. Groups were selected randomly after coin-toss for the first surgery to be ALBG-PRP.

Interventions: Pre- and post-surgery cleft defect severity was registered by a score system using superimposed digitalized peri-apical radiographs. The hypothesis indicated ABG-PRP to be similar to the ABG was proved.

Results: There was no statistically significant difference (P < 0.05) in bone augmentation for the ABG-PRP group (79.88%) when compared to the ABG group (79.9%).

Conclusion: ABG-PRP is indicated as a successful treatment modality to reduce the need for additional donor sites and reduce morbidity and hospital stay.

Keywords: Allogeneic bone graft; alveolar cleft grafting; bone reconstructive procedures; chin bone harvest; platelet-rich plasma.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Schematic design delimiting the areas to be incised during the surgical procedure
Figure 2
Figure 2
Reflected flap showing the buccal view of the alveolar defect. Note the extent of the alveolar defect to the nasal mucosa, which was sutured separately prior to bone grafting
Figure 3
Figure 3
Buccal view of the alveolar defect filled with allogeneic bone graft material combined with PRP
Figure 4
Figure 4
Allogeneic bone graft material combined with platelet-rich plasma in the clotting phase
Figure 5
Figure 5
The same material observed in Figure 4 combined with platelet-rich plasma induced bone graft clot
Figure 6
Figure 6
Area considered 100% bone augmentation (ideal bone augmentation) delimited in whiteww
Figure 7
Figure 7
Area of real bone augmentation (ideal bone augmentation) delimited in white
Figure 8
Figure 8
Scale showing the first line drawn on the cervical aspect of the teeth adjacent to the cleft, representing less distortion, and the other lines drawn parallel to this one with a 3 mm distance between them
Graph 1
Graph 1
Confidence intervals in 95% for the digital measurement variable in function of the group (control and test) factor
Graph 2
Graph 2
Confidence intervals in 95% for the digital measurement variable in function of the age (ideal and not ideal) factor
Graph 3
Graph 3
Confidence intervals in 95% for the digital measurement variable in function of the sex (female and male) factor
See this image and copyright information in PMC

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