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Review
. 2021;8(3):163-182.
doi: 10.1007/s40472-021-00330-5. Epub 2021 Jun 29.

COVID-19 and the Response of Transplant Centers: the Global Response with an Emphasis on the Kidney Recipient

Affiliations
Review

COVID-19 and the Response of Transplant Centers: the Global Response with an Emphasis on the Kidney Recipient

Yorg Azzi et al. Curr Transplant Rep. 2021.

Abstract

Purpose of the review: In response to the COVID-19 pandemic, vulnerable populations, such as transplant patients, were at greater risk than the regular population. In order to protect these populations, transplant centers enacted new guidelines. We approach this review by looking at how different transplant regions responded to COVID-19 and analyze the unifying themes that have proven invaluable in the subsequent waves.

Recent findings: We noticed that most elective surgeries including living donor transplant operations were suspended in most countries. The response to deceased donor transplants varied between countries: in some deceased donor transplants continued with modified donor and recipient criteria, while in other countries this surgery was suspended. There was a general trend of decreasing or holding antimetabolites, treating the virus with hydroxychloroquine and/or azithromycin, and converting outpatient clinics to virtual clinics.

Summary: We learned how to carefully select donors and recipients, tailor immunosuppressant regiments, and implement telemedicine. The kidney recipient population can be effectively managed in times of crisis with appropriate accommodations and measures. This review can be a model for the transplant community for future pandemics.

Keywords: COVID-19 in the transplant community; Kidney recipients and COVID-19; Review of transplant response to COVID-19; Transplant response to COVID-19.

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Conflict of interest statement

Conflict of InterestYorg Azzi, Abigail Brooks, Hillary Yaffe, and Stuart Greenstein declare no conflict of interest.

References

    1. Ahn C, Amer H, Anglicheau D, Ascher NL, Baan CC, Battsetset G, et al. Global transplantation COVID report March 2020. Transplantation. 2020;104(10):1974–1983. doi: 10.1097/TP.0000000000003258. - DOI - PMC - PubMed
    1. Zhu L, Gong N, Liu B, Lu X, Chen D, Chen S, et al. Coronavirus disease 2019 pneumonia in immunosuppressed renal transplant recipients: a summary of 10 confirmed cases in Wuhan, China. Eur Urol. 2020;77(6):748–754. doi: 10.1016/j.eururo.2020.03.039. - DOI - PMC - PubMed
    1. Mohamed IH, Chowdary PB, Shetty S, Sammartino C, Sivaprakasam R, Lindsey B, Thuraisingham R, Yaqoob MM, Khurram MA. Outcomes of renal transplant recipients with SARS-CoV-2 infection in the eye of the storm: a comparative study with waitlisted patients. Transplantation. 2021;105(1):115–120. doi: 10.1097/TP.0000000000003406. - DOI - PubMed
    1. Benotmane I, Perrin P, Vargas GG, Bassand X, Keller N, Lavaux T, Ohana M, Bedo D, Baldacini C, Sagnard M, Bozman DF, Chiesa MD, Cognard N, Olagne J, Delagreverie H, Marx D, Heibel F, Braun L, Moulin B, Fafi-Kremer S, Caillard S. Biomarkers of cytokine release syndrome predict disease severity and mortality from COVID-19 in kidney transplant recipients. Transplantation. 2021;105(1):158–169. doi: 10.1097/TP.0000000000003480. - DOI - PubMed
    1. Yi SG, Rogers AW, Saharia A, Aoun M, Faour R, Abdelrahim M, Knight RJ, Grimes K, Bullock S, Hobeika M, McMillan R, Mobley C, Moaddab M, Huang HJ, Bhimaraj A, Ghobrial RM, Gaber AO. Early experience with COVID-19 and solid organ transplantation at a US high-volume transplant center. Transplantation. 2020;104(11):2208–2214. doi: 10.1097/TP.0000000000003339. - DOI - PMC - PubMed

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