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Review
. 2021 Jun 18:9:651161.
doi: 10.3389/fcell.2021.651161. eCollection 2021.

Regulation of Osteoclastogenesis and Bone Resorption by miRNAs

Kazuki Inoue  1   2 , Courtney Ng  1 , Yuhan Xia  1 , Baohong Zhao  1   2   3
Affiliations
Review

Regulation of Osteoclastogenesis and Bone Resorption by miRNAs

Kazuki Inoue et al. Front Cell Dev Biol. .

Abstract

Osteoclasts are specialized bone-resorbing cells that contribute to physiological bone development and remodeling in bone metabolism throughout life. Abnormal production and activation of osteoclasts lead to excessive bone resorption in pathological conditions, such as in osteoporosis and in arthritic diseases with bone destruction. Recent epigenetic studies have shed novel insight into the dogma of the regulation of gene expression. microRNAs belong to a category of epigenetic regulators, which post-transcriptionally regulate and silence target gene expression, and thereby control a variety of biological events. In this review, we discuss miRNA biogenesis, the mechanisms utilized by miRNAs, several miRNAs that play important roles in osteoclast differentiation, function, survival and osteoblast-to-osteoclast communication, and their translational potential and challenges in bone biology and skeletal diseases.

Keywords: bone resorption; miRNA; osteoclast; osteoporosis; rheumatoid arthritis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
miRNA-mediated regulatory network in osteoclastogenesis. *miR-155 and miR223 play dual roles in osteoclastogenesis.
See this image and copyright information in PMC

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