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. 2021 Jun 16:8:686234.
doi: 10.3389/fcvm.2021.686234. eCollection 2021.

The Role of Fasting LDL-C Levels in Their Non-fasting Reduction in Patients With Coronary Heart Disease

Qiuzhen Lin  1   2   3   4 , Yan Fu  1   2   3   4 , XueYan Zang  1   2   3   4 , Qiming Liu  1   2   3   4 , Ling Liu  1   2   3   4
Affiliations

The Role of Fasting LDL-C Levels in Their Non-fasting Reduction in Patients With Coronary Heart Disease

Qiuzhen Lin et al. Front Cardiovasc Med. .

Abstract

The level of low-density lipoprotein cholesterol (LDL-C) decreases to a certain extent after daily meals; however, the influencing factor of this phenomenon has not been fully elucidated. This study included 447 patients with coronary heart disease (CHD). Serum levels of blood lipid parameters at 0, 2, and 4 hours (h) after a daily breakfast were monitored in all subjects. The levels of total cholesterol (TC), LDL-C, high-density lipoprotein cholesterol (HDL-C) and non-HDL-C significantly decreased, while those of triglycerides (TG) and remnant cholesterol (RC) significantly increased from baseline to 4 h in both male and female patients (P < 0.05). Multiple linear regression analysis showed that fasting LDL-C level, the non-fasting change in RC level at 4 h and fasting TG level were significant predictors of the non-fasting change in LDL-C level at 4 h in patients with CHD, and fasting LDL-C level was the most significantly associated with the non-fasting change in LDL-C level. Patients with lower levels of fasting LDL-C had smaller non-fasting changes in LDL-C levels. When the fasting LDL-C level was <1.4 mmol/L, both absolute reduction and percent reduction in LDL-C level at 4 h were almost zero, which means that the non-fasting LDL-C level at 4 h was approximately equivalent to its fasting value (P < 0.05). This result indicated that the non-fasting changes in LDL-C levels were influenced by fasting LDL-C levels in patients with CHD. When the fasting LDL-C level was <1.4 mmol/L, the non-fasting LDL-C level could replace the fasting value to guide treatment.

Keywords: LDL-C; change; coronary heart disease; fasting; non-fasting.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Comparisons of blood lipids in patients with CHD between male and female after a daily breakfast. Comparisons of TC (A), LDL-C (B), TG (C), HDL-C (D), non-HDL-C (E) and RC (F) levels between male and female patients with CHD. #P < 0.05 when compared with fasting value within the same group, *P < 0.05 when compared with those of female patients at the same time point.
Figure 2
Figure 2
Comparisons of the blood lipids levels among three subgroups of patients with CHD after a daily breakfast. Comparisons of TC (A), LDL-C (B), TG (C), HDL-C (D), non-HDL-C (E) and RC (F) levels among three subgroups after a daily breakfast. #P < 0.05 when compared with fasting value within the same subgroup, *P < 0.05 when the subgroup 2 compared with the subgroup 1 at the same time point, &P < 0.05 when the subgroup 3 compared with the subgroup 1 at the same time point, # in (D) meant non-fasting HDL-C values were significantly lower than those of fasting values in subgroup 1 and subgroup 2.
Figure 3
Figure 3
Comparisons of the non-fasting changes and changed percents in LDL-C levels among patients with different fasting LDL-C levels after a daily breakfast. (A,B) Comparisons of the non-fasting changes of LDL-C levels among patients with different fasting LDL-C levels at 2 and 4 h, respectively. (C,D) Comparisons of the non-fasting changed percents of LDL-C levels among patients with different fasting LDL-C levels at 2 and 4 h, respectively. *P < 0.05 the difference between two subgroups reached statistical significance.
See this image and copyright information in PMC

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