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Review
. 2021 Jun 26;9(18):4491-4499.
doi: 10.12998/wjcc.v9.i18.4491.

Current treatment for hepatitis C virus/human immunodeficiency virus coinfection in adults

Ratchapong Laiwatthanapaisan  1 , Apichet Sirinawasatien  2
Affiliations
Review

Current treatment for hepatitis C virus/human immunodeficiency virus coinfection in adults

Ratchapong Laiwatthanapaisan et al. World J Clin Cases. .

Abstract

Hepatitis C virus (HCV)/human immunodeficiency virus (HIV) coinfection is a major problem among HIV-infected patients, resulting in increased morbidity and mortality rates due to the acceleration of liver fibrosis progression by HIV, leading to liver cirrhosis and hepatocellular carcinoma. Although the efficacy of direct-acting antiviral therapy in patients with HIV/HCV coinfection and HCV monoinfection are similar in terms of sustained virologic response rate, there are some additional complications that arise in the treatment of patients with HIV/HCV coinfection, including drug-drug interactions and HCV reinfection due to the high risk behavior of these patients. This review will summarize the current management of HIV/HCV coinfection.

Keywords: Antiretroviral therapy; Cirrhosis; Direct-acting antiviral agents; Hepatocellular carcinoma; Human immunodeficiency virus, Liver fibrosis; Viral hepatitis C.

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Conflict of interest statement

Conflict-of-interest statement: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1
The hepatitis C virus/human immunodeficiency virus coinfection treatment algorithm. ART: Antiretroviral therapy; DAA: Direct-acting antiviral; HCC: Hepatocellular carcinoma; HCV: Hepatitis C virus; HIV: Human immunodeficiency virus; SVR: Sustained virologic response.
See this image and copyright information in PMC

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