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Review
. 2019 Aug 26;1(2):dlz026.
doi: 10.1093/jacamr/dlz026. eCollection 2019 Sep.

Updated good practice recommendations for outpatient parenteral antimicrobial therapy (OPAT) in adults and children in the UK

Ann L N Chapman  1 , Sanjay Patel  2 , Carolyne Horner  3 , Helen Green  2 , Achyut Guleri  4 , Sara Hedderwick  5 , Susan Snape  6 , Julie Statham  7 , Elizabeth Wilson  8 , Mark Gilchrist  9 , R Andrew Seaton  10
Affiliations
Review

Updated good practice recommendations for outpatient parenteral antimicrobial therapy (OPAT) in adults and children in the UK

Ann L N Chapman et al. JAC Antimicrob Resist. .

Abstract

UK good practice recommendations for outpatient parenteral antimicrobial therapy (OPAT) were published in 2012 and 2015 for adult and paediatric patients, respectively. Here we update the initial good practice recommendations in a combined document based on a further review of the OPAT literature and an extensive consultation process. As with the previous good practice recommendations, these updated recommendations are intended to provide pragmatic guidance for new and established OPAT services across a range of settings and to act as a set of quality indicators for service evaluation and quality improvement.

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Figures

Figure 1.
Figure 1.
Flow diagram illustrating the process of the literature search.
Figure 2.
Figure 2.
OPAT team and service structure. Text in italics denotes a new recommendation or a previous recommendation that has been amended.
Figure 3.
Figure 3.
Patient selection. Text in italics denotes a new recommendation or a previous recommendation that has been amended.
Figure 4.
Figure 4.
Antimicrobial management and drug delivery. Text in italics denotes a new recommendation or a previous recommendation that has been amended.
Figure 5.
Figure 5.
Monitoring of the patient during OPAT. Text in italics denotes a new recommendation or a previous recommendation that has been amended.
Figure 6.
Figure 6.
Outcome monitoring and clinical governance. Text in italics denotes a new recommendation or a previous recommendation that has been amended.
See this image and copyright information in PMC

References

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    1. Bryant PA, Katz NT.. Inpatient versus outpatient parenteral antibiotic therapy at home for acute infections in children: a systematic review. Lancet Infect Dis 2018; 18: e45–54. - PubMed
    1. Chapman AL. Outpatient parenteral antimicrobial therapy. BMJ 2013; 346: f1585. - PubMed
    1. Durojaiye OC, Bell H, Andrews D. et al. Clinical efficacy, cost analysis and patient acceptability of outpatient parenteral antibiotic therapy (OPAT): a decade of Sheffield (UK) OPAT service. Int J Antimicrob Agents 2018; 51: 26–32. - PubMed
    1. MacKenzie M, Rae N, Nathwani D.. Outcomes from global adult outpatient parenteral antimicrobial therapy programmes: a review of the last decade. Int J Antimicrob Agents 2014; 43: 7–16. - PubMed

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