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. 2021 Jan 30:5:100081.
doi: 10.1016/j.resplu.2021.100081. eCollection 2021 Mar.

Vasopressin and methylprednisolone for in-hospital cardiac arrest - Protocol for a randomized, double-blind, placebo-controlled trial

Lars W Andersen  1   2   3 , Birthe Sindberg  1 , Mathias Holmberg  1   4 , Dan Isbye  5 , Jesper Kjærgaard  6 , Stine T Zwisler  7 , Søren Darling  7 , Jacob Moesgaard Larsen  8   9 , Bodil S Rasmussen  9   10 , Bo Løfgren  1   11 , Kasper Glerup Lauridsen  1   11 , Kim B Pælestik  12 , Christoffer Sølling  12 , Anders G Kjærgaard  13 , Dorte Due-Rasmussen  13 , Fredrik Folke  14   15 , Mette Gitz Charlot  15 , Kasper Iversen  16 , Martin Schultz  17 , Sebastian Wiberg  18 , Rikke Malene H G Jepsen  18 , Tobias Kurth  19 , Michael Donnino  20   21 , Hans Kirkegaard  1   3 , Asger Granfeldt  2
Affiliations

Vasopressin and methylprednisolone for in-hospital cardiac arrest - Protocol for a randomized, double-blind, placebo-controlled trial

Lars W Andersen et al. Resusc Plus. .

Abstract

Objective: To describe the clinical trial "Vasopressin and Methylprednisolone for In-Hospital Cardiac Arrest" (VAM-IHCA).

Methods: The VAM-IHCA trial is an investigator-initiated, multicenter, randomized, placebo-controlled, parallel group, double-blind, superiority trial of vasopressin and methylprednisolone during adult in-hospital cardiac arrest. The study drugs consist of 40 mg methylprednisolone and 20 IU of vasopressin given as soon as possible after the first dose of adrenaline. Additional doses of vasopressin (20 IU) will be administered after each adrenaline dose for a maximum of four doses (80 IU).The primary outcome is return of spontaneous circulation and key secondary outcomes include survival and survival with a favorable neurological outcome at 30 days. 492 patients will be enrolled. The trial was registered at the EU Clinical Trials Register (EudraCT Number: 2017-004773-13) on Jan. 25, 2018 and ClinicalTrials.gov (Identifier: NCT03640949) on Aug. 21, 2018.

Results: The trial started in October 2018 and the last patient is anticipated to be included in January 2021. The primary results will be reported after 3-months follow-up and are, therefore, anticipated in mid-2021.

Conclusion: The current article describes the design of the VAM-IHCA trial. The results from this trial will help clarify whether the combination of vasopressin and methylprednisolone when administered during in-hospital cardiac arrest improves outcomes.

Keywords: In-hospital cardiac arrest; Methylprednisolone; Randomized trial; Vasopressin.

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Figures

Fig. 1
Fig. 1
Overview of the trial interventions.
See this image and copyright information in PMC

References

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    1. Andersen L.W., Holmberg M.J., Berg K.M., Donnino M.W., Granfeldt A. In-hospital cardiac arrest: a review. JAMA. 2019;321:1200–1210. - PMC - PubMed

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