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. 2021 Jul:16:801-810.
doi: 10.2217/fmb-2020-0243. Epub 2021 Jul 5.

Evidence of bacterial DNA presence in chorionic villi and amniotic fluid in the first and second trimester of pregnancy

Giuseppina Campisciano  1 , Mariachiara Quadrifoglio  2 , Manola Comar  1 , Francesco De Seta  3   4 , Nunzia Zanotta  1 , Chiara Ottaviani  3 , Moira Barbieri  2 , Antonella Chiodo  5 , Tamara Stampalija  2   3
Affiliations

Evidence of bacterial DNA presence in chorionic villi and amniotic fluid in the first and second trimester of pregnancy

Giuseppina Campisciano et al. Future Microbiol. 2021 Jul.

Erratum in

  • Corrigendum.
    [No authors listed] [No authors listed] Future Microbiol. 2021 Sep;16:1152. doi: 10.2217/fmb-2020-0243c1. Epub 2021 Sep 9. Future Microbiol. 2021. PMID: 34496613 No abstract available.

Abstract

The sterile-womb dogma in uncomplicated pregnancy has been lively debated. Data regarding the in utero microbiome environment are based mainly on studies performed at the time of delivery. Aim: To determine whether human placenta and amniotic fluid are populated by a bacterial microbiota in the first and second trimesters of pregnancy. Materials & methods: We analyzed by next-generation sequencing method 24 and 29 samples from chorionic villus sampling (CVS) and amniocentesis (AC), respectively. The V3 region of the 16S rRNA gene was sequenced. Results: 37.5% of CVS and 14% of AC samples showed the presence of bacterial DNA. Conclusion: Our study suggests that bacterial DNA can be identified in the placenta and amniotic fluid during early prenatal life.

Keywords: amniocentesis; chorionic villous sampling; microbiome; placenta.

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