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. 2021 Jul 1;49(4):180-186.
doi: 10.15586/aei.v49i4.387. eCollection 2021.

Possible presence of undiagnosed asthma in children in Japan

Yagi Yuichiro  1 , Kuzume Kazuyo  2   3 , Kumagai Hideki  4
Affiliations

Possible presence of undiagnosed asthma in children in Japan

Yagi Yuichiro et al. Allergol Immunopathol (Madr). .

Abstract

Background: Asthma diagnosis in children is occasionally challenging, and the issue of undiagnosed asthma before adolescence has been poorly studied in Japan. The present study was conducted to investigate the possible presence of undiagnosed asthma in the general population of children living in a rural area of Japan.

Methods: The participants comprised 120 fourth graders aged 9-10 years (boys/girls: 63/57) attending five elementary schools in Yawatahama, Ehime, Japan. All the children underwent respiratory function tests and fraction of exhaled nitric oxide (FeNO) measurements. Based on the results of a questionnaire, the children were also categorized into groups depending on their allergic diseases.The authors assessed the results of both the respiratory function tests and the FeNO measurements for children who were classified into the nonallergic group.

Results: A total of 76 (63%) children, who completed the tests appropriately, were included in the analysis. According to the report, among the 24 children in the nonallergic group, six (25%) showed abnormalities in respiratory tests. One had an abnormal % forced vital capacity (%FVC; <80%), three had abnormalities in both forced expiratory volume in 1 sec (FEV1)/FVC (<80%) and % maximal mid-expiratory flow (<65%), three had concave flow-volume curves, and one had a high FeNO measurement (41 ppb).

Conclusion: A certain proportion of Japanese elementary school children, categorized as having no allergy, showed respiratory function test abnormalities. A follow-up study is needed to determine the prognosis and outcomes of the children with these abnormalities.

Keywords: Children; FeNO; pulmonary function test; undiagnosed asthma.

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Conflict of interest statement

The authors declare no potential conflicts of interest with respect to research, authorship, and/or publication of this article.

References

    1. 1. Global Initiative for Asthma. GINA guidelines. Global strategy for asthma management and prevention, 2019 [Internet]. [Accessed 2020 Feb 1]. Available from: https://ginasthma.org/
    1. 2. Dweik RA, Boggs PB, Erzurum SC, Irvin CG, Leigh MW, Lundberg JO, et al. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am J Respir Crit Care Med. 2011 Sep 1;184(5):602–15. 10.1164/rccm.9120-11ST - DOI
    1. 3. Van Gent R, Van Essen-Zandvliet LEM, Rovers MM, Kimpen JLL, De Meere G, Van Der Ent CK. Poor perception of dyspnoea in children with undiagnosed asthma. Eur Respir J. 2007 Nov;30(5):887–91. 10.1183/09031936.00031407 - DOI
    1. 4. Aaron SD, Boulet LP, Reddel HK, Gershon AS. Underdiagnosis and overdiagnosis of asthma. Am J Respir Crit Care Med. 2018 Oct 15;198(8):1012–20. 10.1164/rccm.201804-0682CI - DOI
    1. 5. McGeachie MJ, Yates KP, Zhou X, Guo F, Sternberg AL, Van Natta ML, et al. Patterns of growth and decline in lung function in persistent childhood asthma. N Engl J Med. 2016 May 12;374(19):1842–52. 10.1056/NEJMoa1513737 - DOI