Visual Disturbances and Headache as Presenting Symptoms of Creutzfeldt-Jakob Disease

Affiliations

¹ Department of Ophthalmology and Visual Sciences (NMB, MJS, IJ), University of Alberta, Edmonton, Canada ; Department of Medicine, Division of Neurology (NN, VLS), University of Alberta, Edmonton, Canada; and Department of Radiology and Diagnostic Imaging (DJ), University of Alberta, Edmonton, Canada.

Natalia M Binczyk et al. J Neuroophthalmol. 2022.

. 2022 Jun 1;42(2):e488-e490.

doi: 10.1097/WNO.0000000000001293. Epub 2021 Jul 1.

¹ Department of Ophthalmology and Visual Sciences (NMB, MJS, IJ), University of Alberta, Edmonton, Canada ; Department of Medicine, Division of Neurology (NN, VLS), University of Alberta, Edmonton, Canada; and Department of Radiology and Diagnostic Imaging (DJ), University of Alberta, Edmonton, Canada.

No abstract available

Conflict of interest statement

The authors report no conflicts of interest.

1. Cooper SA, Murray KL, Heath CA, Will RG, Knight RSG. Isolated visual symptoms at onset in sporadic Creutzfeldt-Jakob disease: the clinical phenotype of the “Heidenhain variant”. Br J Ophthalmol. 2005;89:1341–1342.
1. Shiga Y, Miyazawa K, Sato S, Fukushima R, Shibuya S, Sato Y, Konno H, Doh-ura K, Mugikura S, Tamura H, Higano S, Takahashi S, Itoyama Y. Diffusion-weighted MRI abnormalities as an early diagnostic marker for Creutzfeldt-Jakob disease. Neurology. 2004;63:443–449.
1. Manners DN, Parchi P, Tonon C, Capellari S, Strammiello R, Testa C, Tani G, Malucelli E, Spagnolo C, Cortelli P, Montagna P, Lodi R, Barbiroli B. Pathologic correlates of diffusion MRI changes in Creutzfeldt–Jakob disease. Neurology. 2009;72:1425–1431.
1. Wilham JM, Orrú CD, Bessen RA, Atarashi R, Sano K, Race B, Meade-White KD, Taubner LM, Timmes A, Caughey B. Rapid end-point quantitation of prion seeding activity with sensitivity comparable to bioassays. PLoS Pathog. 2010;6:e1001217.
1. Cheng K, Vendramelli R, Sloan A, Waitt B, Podhorodecki L, Godal D, Knox JD. Endpoint quaking-induced conversion: a sensitive, specific, and high-throughput method for antemortem diagnosis of Creutzfeldt-Jacob disease. J Clin Microbiol. 2016;54:1751–1754.