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Review
. 2021 Nov 1;149(9):1628-1638.
doi: 10.1002/ijc.33731. Epub 2021 Jul 17.

Tumor promoting capacity of polymorphonuclear myeloid-derived suppressor cells and their neutralization

Christopher Groth  1   2   3   4   5 , Rebekka Weber  1   2   3 , Samantha Lasser  1   2   3   6 , Feyza Gül Özbay  1   2   3   6 , Annina Kurzay  1   2   6 , Vera Petrova  1   2   3 , Peter Altevogt  1   2   3 , Jochen Utikal  1   2 , Viktor Umansky  1   2   3
Affiliations
Review

Tumor promoting capacity of polymorphonuclear myeloid-derived suppressor cells and their neutralization

Christopher Groth et al. Int J Cancer. .

Abstract

Myeloid-derived suppressor cells (MDSC) represent a highly immunosuppressive population that expands in tumor bearing hosts and inhibits both T and NK cell antitumor effector functions. Among MDSC subpopulations, the polymorphonuclear (PMN) one is gaining increasing interest since it is a predominant MDSC subset in most cancer entities and inherits unique properties to facilitate metastatic spread. In addition, further improvement in distinguishing PMN-MDSC from neutrophils has contributed to the design of novel therapeutic approaches. In this review, we summarize the current view on the origin of PMN-MDSC and their relation to classical neutrophils. Furthermore, we outline the metastasis promoting features of these cells and promising strategies of their targeting to improve the efficacy of cancer immunotherapy.

Keywords: PMN-MDSC; immunosuppression; immunotherapy; metastasis; neutrophils.

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References

REFERENCES

    1. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144:646-674.
    1. Cornel AM, Mimpen IL, Nierkens S. MHC class I downregulation in cancer: underlying mechanisms and potential targets for cancer immunotherapy. Cancer. 2020;12:1760.
    1. Labani-Motlagh A, Ashja-Mahdavi M, Loskog A. The tumor microenvironment: A milieu hindering and obstructing antitumor immune responses. Front Immunol. 2020;11:940.
    1. Bronte V, Brandau S, Chen S-H, et al. Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards. Nat Commun. 2016;7:12150.
    1. Jensen HK, Donskov F, Marcussen N, Nordsmark M, Lundbeck F, von der Maase H. Presence of intratumoral neutrophils is an independent prognostic factor in localized renal cell carcinoma. J Clin Oncol. 2009;27:4709-4717.

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