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Review
. 2021 Sep:176:113851.
doi: 10.1016/j.addr.2021.113851. Epub 2021 Jul 2.

Liposome composition in drug delivery design, synthesis, characterization, and clinical application

Danielle E Large  1 , Rudolf G Abdelmessih  1 , Elizabeth A Fink  1 , Debra T Auguste  2
Affiliations
Review

Liposome composition in drug delivery design, synthesis, characterization, and clinical application

Danielle E Large et al. Adv Drug Deliv Rev. 2021 Sep.

Abstract

Liposomal drug delivery represents a highly adaptable therapeutic platform for treating a wide range of diseases. Natural and synthetic lipids, as well as surfactants, are commonly utilized in the synthesis of liposomal drug delivery vehicles. The molecular diversity in the composition of liposomes enables drug delivery with unique physiological functions, such as pH response, prolonged blood circulation, and reduced systemic toxicity. Herein, we discuss the impact of composition on liposome synthesis, function, and clinical utility.

Keywords: Liposomal drug delivery; Liposome functionality; Liposome synthesis.

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