Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Aug;41(3):481-491.
doi: 10.1016/j.iac.2021.04.008. Epub 2021 Jun 5.

Protein Causes of Urticaria and Dermatitis

Alyssa Gwen Ashbaugh  1 , Mary Kathryn Abel  2 , Jenny E Murase  3
Affiliations
Review

Protein Causes of Urticaria and Dermatitis

Alyssa Gwen Ashbaugh et al. Immunol Allergy Clin North Am. 2021 Aug.

Abstract

Protein contact dermatitis is a cutaneous hypersensitivity reaction after chronic, recurrent exposure or chronic irritation to animal or plant protein. Although the pathophysiological mechanisms underlying protein contact dermatitis are not well characterized, protein contact dermatitis is thought to be caused by combined type I/IV-mediated, type-1 mediated, or a Langerhans cell immunoglobulin E-mediated delayed hypersensitivity reaction. This chapter reviews the epidemiology, pathogenesis, clinical features, common protein allergens, diagnostic process, treatment options, and prognosis of protein contact dermatitis.

Keywords: Allergy; Cutaneous hypersensitivity reaction; Protein contact dermatitis.

PubMed Disclaimer

Conflict of interest statement

Disclosure The authors have nothing to disclose.