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Review
. 2021 Jun 21;7(1):163.
doi: 10.1038/s41420-021-00532-x.

The emerging role of WWP1 in cancer development and progression

Xiaoli Hu  1 , Jiangtao Yu  1 , Zixia Lin  2   3 , Renqian Feng  1 , Zhi-Wei Wang  4 , Gang Chen  5   6
Affiliations
Review

The emerging role of WWP1 in cancer development and progression

Xiaoli Hu et al. Cell Death Discov. .

Abstract

Emerging evidence demonstrates that WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) participates into carcinogenesis and tumor progression. In this review article, we will describe the association between dysregulated WWP1 expression and clinical features of cancer patients. Moreover, we summarize the both oncogenic and tumor suppressive functions of WWP1 in a variety of human cancers. Furthermore, we briefly describe the downstream substrates of WWP1 and its upstream factors to regulate the expression of WWP1. Notably, targeting WWP1 by its inhibitors or natural compounds is potentially useful for treating human malignancies. Finally, we provide the perspectives regarding WWP1 in cancer development and therapies. We hope this review can stimulate the research to improve our understanding of WWP1-mediated tumorigenesis and accelerate the discovery of novel therapeutic strategies via targeting WWP1 expression in cancers.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
The chemical constitution of WWP1.
Fig. 2
Fig. 2
WWP1 expression is associated with overall survival in a variety of human cancers.
Fig. 3
Fig. 3
The upstream mediators and downstream substrates of WWP1.
See this image and copyright information in PMC

References

    1. Bedford L, Lowe J, Dick LR, Mayer RJ, Brownell JE. Ubiquitin-like protein conjugation and the ubiquitin-proteasome system as drug targets. Nat Rev Drug Discov. 2011;10:29–46. doi: 10.1038/nrd3321. - DOI - PMC - PubMed
    1. Ciechanover A. Proteolysis: from the lysosome to ubiquitin and the proteasome. Nat Rev Mol Cell Biol. 2005;6:79–87. doi: 10.1038/nrm1552. - DOI - PubMed
    1. Muratani M, Tansey WP. How the ubiquitin-proteasome system controls transcription. Nat Rev Mol Cell Biol. 2003;4:192–201. doi: 10.1038/nrm1049. - DOI - PubMed
    1. Lipkowitz S, Weissman AM. RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis. Nat Rev Cancer. 2011;11:629–43. doi: 10.1038/nrc3120. - DOI - PMC - PubMed
    1. Wang P, Dai X, Jiang W, Li Y, Wei W. RBR E3 ubiquitin ligases in tumorigenesis. Semin Cancer Biol. 2020;67:131–44. doi: 10.1016/j.semcancer.2020.05.002. - DOI - PubMed