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Case Reports
. 1988 Jan;95(1):116-20.
doi: 10.1016/s0161-6420(88)33213-6.

Early onset acute orbital involvement in childhood acute lymphoblastic leukemia

R S Rubinfeld  1 , J E Gootenberg, R M Chavis, L E Zimmerman
Affiliations
Case Reports

Early onset acute orbital involvement in childhood acute lymphoblastic leukemia

R S Rubinfeld et al. Ophthalmology. 1988 Jan.

Abstract

A 5-year-old girl with acute lymphoblastic leukemia undergoing induction chemotherapy experienced acute proptosis while agranulocytotic and febrile. Orbital biopsy showed leukemic infiltration, and complete resolution was achieved with local irradiation and chemotherapy. Early onset orbital involvement is highly unusual in acute lymphoblastic leukemia. In the setting of agranulocytosis and fever, rapidly enlarging intraorbital masses require urgent ophthalmologic attention. Immediate biopsy is indicated to distinguish between several treatable conditions including opportunistic infection, hemorrhage, and neoplastic infiltration.

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