Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jan;31(1-2):62-86.
doi: 10.1111/jocn.15951. Epub 2021 Jul 6.

COVID-19 vaccination intention in the first year of the pandemic: A systematic review

Affiliations

COVID-19 vaccination intention in the first year of the pandemic: A systematic review

Rasmieh Al-Amer et al. J Clin Nurs. 2022 Jan.

Abstract

Aims and objectives: To synthesise evidence regarding vaccination intention, identify factors contributing to vaccine hesitancy among healthcare professionals and the general populations globally.

Background: As COVID-19 vaccine becomes available worldwide, attention is being directed to community vaccine uptake, to achieve population-wide immunity. A number of factors have been reported to influence vaccine intention.

Methods: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a systematic search of COVID-19 vaccination intention related literature published on or before 31 December 2020 from seven databases was undertaken.

Results: Thirty articles were included in this systematic review. Overall COVID-19 vaccination intention during the first year of the pandemic ranged from 27.7% to 93.3%. Findings highlighted that socio-demographic differences, perceptions of risk and susceptibility to COVID-19 and vaccine attributes influenced vaccination intention. Healthcare professionals particularly, nurses have higher vaccine hesitancy reportedly due to concerns regarding vaccine safety and efficacy and mistrust of health authorities. Negative information about COVID-19 vaccines in the social media and low confidence in the health system were associated with lower acceptability among the community. Interestingly, cumulative increase in COVID-19 caseloads of countries over time was not associated with vaccination intention.

Conclusions: The significant variability in vaccine intention rates worldwide would hamper efforts to achieve immunity against COVID-19. Nurses' concerns about vaccine safety and efficacy need to be addressed to increase vaccine acceptance and maximise their influence on vaccination decision in the community. As misinformation through social media negatively impacts vaccination uptake, authoritative and reliable information on vaccine attributes, disease risks and vaccination benefits are needed.

Relevance to clinical practice: Concerns about vaccine safety and efficacy including misinformation are important contributors to vaccine hesitancy. Addressing these factors, particularly among nurses who are considered trusted influencers of vaccination decisions in the community is an important strategy for pandemic preparedness.

Keywords: COVID-19; coronavirus; vaccination; vaccine acceptance; vaccine hesitancy; vaccine uptake.

PubMed Disclaimer

Conflict of interest statement

No conflict of interest has been declared by the authors.

Figures

FIGURE 1
FIGURE 1
Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) flow chart for the systematic review
FIGURE 2
FIGURE 2
Cumulative mean number of COVID‐19 cases per 1 million population and overall percentages vaccination intention

References

    1. Al‐Mohaithef, M. , & Padhi, B. K. (2020). Determinants of COVID‐19 vaccine acceptance in Saudi Arabia: A web‐based national survey. Journal of Multidisciplinary Healthcare, 13, 1657–1663. 10.2147/JMDH.S276771 - DOI - PMC - PubMed
    1. Barello, S. , Nania, T. , Dellafiore, F. , Graffigna, G. , & Caruso, R. (2020). ‘Vaccine hesitancy’ among university students in Italy during the COVID‐19 pandemic. European Journal of Epidemiology, 35(8), 781–783. 10.1007/s10654-020-00670-z - DOI - PMC - PubMed
    1. Bertin, P. , Nera, K. , & Delouvée, S. (2020). Conspiracy beliefs, rejection of vaccination, and support for hydroxychloroquine: A conceptual replication‐extension in the COVID‐19 pandemic context [Article]. Frontiers in Psychology, 11, Article 565128. 10.3389/fpsyg.2020.565128 - DOI - PMC - PubMed
    1. Bogart, L. M. , Ojikutu, B. O. , Tyagi, K. , Klein, D. J. , Mutchler, M. G. , Dong, L. , Lawrence, S. J. , Thomas, D. , & Kellman, S. (2020). COVID‐19 related medical mistrust, health impacts, and potential vaccine hesitancy among black Americans living with HIV. Journal of Acquired Immune Deficiency Syndromes, 86(2), 200–207. 10.1097/QAI.0000000000002570 - DOI - PMC - PubMed
    1. Dodd, R. H. , Cvejic, E. , Bonner, C. , Pickles, K. , McCaffery, K. J. , Ayre, J. , Batcup, C. , Copp, T. , Cornell, S. , Dakin, T. , Isautier, J. M. , Nickel, B. , & Sydney Health Literacy Lab, C.‐G. (2020). Willingness to vaccinate against COVID‐19 in Australia. The Lancet Infectious Diseases. 10.1016/S1473-3099(20)30559-4 - DOI - PMC - PubMed

Publication types

Substances