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Multicenter Study
. 2021 Nov;23(11):2484-2491.
doi: 10.1111/dom.14491. Epub 2021 Aug 2.

Effectiveness of a closed-loop control system and a virtual educational camp for children and adolescents with type 1 diabetes: A prospective, multicentre, real-life study

Valentino Cherubini  1 , Ivana Rabbone  2 , Maria Giulia Berioli  3 , Sara Giorda  4 , Donatella Lo Presti  5 , Giulio Maltoni  6 , Chiara Mameli  7 , Marco Marigliano  8 , Monica Marino  1 , Nicola Minuto  9 , Enza Mozzillo  10 , Elvira Piccinno  11 , Barbara Predieri  12 , Carlo Ripoli  13 , Riccardo Schiaffini  14 , Andrea Rigamonti  15 , Giuseppina Salzano  16 , Davide Tinti  4 , Sonia Toni  17 , Angela Zanfardino  18 , Andrea E Scaramuzza  19 , Rosaria Gesuita  20 ; vEC Study Group; Valentina Tiberi  1 , Silvia Savastio  2 , Ciro Pigniatiello  2 , Michela Trada  4 , Stefano Zucchini  6 , Francesca Chiara Redaelli  7 , Claudio Maffeis  8 , Marta Bassi  9 , Francesco Maria Rosanio  10 , Maurizio Delvecchio  11 , Patrizia Buzzi  12 , Maria Rossella Ricciardi  13 , Chiara Carducci  14 , Riccardo Bonfanti  15 , Fortunato Lombardo  16 , Barbara Piccini  17 , Dario Iafusco  18 , Michela Calandretti  21 , Federico Abate Daga  21
Affiliations
Multicenter Study

Effectiveness of a closed-loop control system and a virtual educational camp for children and adolescents with type 1 diabetes: A prospective, multicentre, real-life study

Valentino Cherubini et al. Diabetes Obes Metab. 2021 Nov.

Abstract

Aim: To evaluate the impact of a virtual educational camp (vEC) on glucose control in children and adolescents with type 1 diabetes using a closed-loop control (CLC) system.

Materials and methods: This was a prospective multicentre study of children and adolescents with type 1 diabetes using the Tandem Basal-IQ system. Insulin pumps were upgraded to Control-IQ, and children and their parents participated in a 3-day multidisciplinary vEC. Clinical data, glucose metrics and HbA1c were evaluated over the 12 weeks prior to the Control-IQ update and over the 12 weeks after the vEC.

Results: Forty-three children and adolescents (aged 7-16 years) with type 1 diabetes and their families participated in the vEC. The median percentage of time in target range (70-180 mg/dL; TIR) increased from 64% (interquartile range [IQR] 56%-73%) with Basal-IQ to 76% (IQR 71%-81%) with Control-IQ (P < .001). After the vEC, more than 75% of participants achieved a TIR of more than 70%. The percentage of time between 180 and 250 mg/dL and above 250 mg/dL decreased by 5% (P < .01) and 6% (P < .01), respectively, while the time between 70 and 54 mg/dL and below 54 mg/dL remained low and unaltered. HbA1c decreased by 0.5% (P < .01). There were no episodes of diabetic ketoacidosis or severe hypoglycaemia.

Conclusions: In this study of children managing their diabetes in a real-world setting, more than 75% of children who participated in a vEC after starting a CLC system could obtain and maintain a TIR of more than 70%. The vEC was feasible and resulted in a significant and persistent improvement in TIR in children and adolescents with type 1 diabetes.

Keywords: CSII; continuous glucose monitoring; glycaemic control; insulin pump therapy; observational study; type 1 diabetes.

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References

REFERENCES

    1. Cherubini V, Bonfanti R, Casertano A, et al. Time in range in children with type 1 diabetes using treatment strategies based on nonautomated insulin delivery systems in the real world. Diabetes Technol Ther. 2020;22(7):509-515.
    1. Breton MD, Kanapka LG, Beck RW, et al. A randomized trial of closed-loop control in children with type 1 diabetes. N Engl J Med. 2020;383(9):836-845.
    1. Alcantara-Aragon V. Improving patients self-care using diabetes technologies. Ther Adv Endocrinol Metab. 2019;10:2042018818824215.
    1. Messer LH, Berget C, Ernst A, Towers L, Slover RH, Forlenza GP. Initiating hybrid closed loop: a program evaluation of an educator-led control-IQ follow-up at a large pediatric clinic. Pediatr Diabetes. 2021;22:586-593.
    1. Scaramuzza A, Cavalli C, Rabbone I. Control-IQ technology enhanced by educative path in diabetes children. Diabetes Res Clin Pract. 2020;169:108525.

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