Doxycycline-induced cholestatic liver injury
- PMID: 34228348
- DOI: 10.1007/s12328-021-01475-7
Doxycycline-induced cholestatic liver injury
Abstract
Doxycycline-induced liver injury is a rare phenomenon, with an unclear clinical course and etiopathogenesis. The onset of injury may be acute-to-subacute, with a pattern ranging from hepatocellular or cholestatic to mixed, and it often lasts up to several weeks. We present a case of cholestatic liver injury secondary to doxycycline use in a middle-aged woman. In patients with a history of doxycycline exposure and subsequent hepatic injury, an adverse drug reaction due to doxycycline should remain on the differential, and immediate removal of the offending agent with close monitoring of the clinical condition should be pursued.
Keywords: Cholestasis; Doxycycline; Drug reaction; Liver injury.
© 2021. This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.
References
-
- Ostapowicz G, Fontana RJ, Schiodt FV, et al. Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. Ann Intern Med. 2002;137:947–54. - DOI
-
- Levy C. Management of pruritus in patients with cholestatic liver disease. Gastroenterol Hepatol. 2011;7:615–7.
-
- Langedijk J, Beuers UH, Oude Elferink RPJ. Cholestasis-associated pruritus and its pruritogens. Front Med. 2021;8:639674. - DOI
-
- Patel SP, Vasavda C, Ho B, et al. Cholestatic pruritus: emerging mechanisms and therapeutics. J Am Acad Dermatol. 2019;81:1371–8. - DOI
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical