Retinotopic organization of visual cortex in human infants

Abstract

Vision develops rapidly during infancy, yet how visual cortex is organized during this period is unclear. In particular, it is unknown whether functional maps that organize the mature adult visual cortex are present in the infant striate and extrastriate cortex. Here, we test the functional maturity of infant visual cortex by performing retinotopic mapping with functional magnetic resonance imaging (fMRI). Infants aged 5-23 months had retinotopic maps, with alternating preferences for vertical and horizontal meridians indicating the boundaries of visual areas V1 to V4 and an orthogonal gradient of preferences from high to low spatial frequencies. The presence of multiple visual maps throughout visual cortex in infants indicates a greater maturity of extrastriate cortex than previously appreciated. The areas showed subtle age-related fine-tuning, suggesting that early maturation undergoes continued refinement. This early maturation of area boundaries and tuning may scaffold subsequent developmental changes.

Keywords: child development; fMRI; fovea and periphery; functional regions of interest; gray-white matter segmentation; receptive fields; topographic mapping; ventral and dorsal streams; visual system.