Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Jul 7;21(1):1338.
doi: 10.1186/s12889-021-11387-3.

The characteristics and trend of adverse events following immunization reported by information system in Jiangsu province, China, 2015-2018

Ran Hu  1 , Shanshan Peng  2 , Yuanbao Liu  1 , Fengyang Tang  1 , Zhiguo Wang  1 , Lei Zhang  1 , Jun Gao  3 , Hongxiong Guo  4
Affiliations

The characteristics and trend of adverse events following immunization reported by information system in Jiangsu province, China, 2015-2018

Ran Hu et al. BMC Public Health. .

Abstract

Objective: Adverse events following immunization is an important factor influencing public trust in vaccination. Publicizing its incidence timely can increase public trust. The aim of this study is to describe the incidence and characteristics of adverse events following immunization in Jiangsu province of China from 2015 to 2018.

Methods: All information of adverse events following immunization (AEFIs) was gained from Jiangsu Province Vaccination Integrated Service Management Information System. The reported AEFI trend was analyzed using Chi-square test.

Results: A total of 77,980 AEFI cases were reported through the AEFI system; Among which, 77,731 were classified as non-serious AEFI cases and 249 were serious AEFI cases. The male to female ratio was 1.31:1, cases less than 7 years old accounted for 97.7%. The total estimated AEFI rate was 62.70/100,000 doses. By severity, 60.75/100,000, 4.46/100,000 and 0.11/100,000 AEFI cases were common vaccine reaction, rare vaccine reaction, and serious rare vaccine reaction, respectively. The top two serious AEFI were thrombocytopenic purpura and febrile. The incidence rates showed the increasing trend and the linear trend of the increasing incidence rates passed the significant test at 0.05 levels.

Conclusion: The sensitivity of AEFI monitoring in Jiangsu Province is increasing and higher than the national average and most countries. The majority of AEFI cases were common adverse reactions, while the serious vaccine reactions caused by vaccines were extremely low. To elevate the sensitivity of AEFI surveillance may reduce the incidence of developing serious AEFI cases.

Keywords: Adverse events following immunization; Categories of vaccine reaction; Common vaccine reaction; Incidence of adverse events following immunization; Serious vaccine reaction; Vaccine.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
The trend of AEFIs incidence from 2015 to 2018 in Jiangsu, China
See this image and copyright information in PMC

References

    1. Lee JS, Louren OJ, Gupta S, Farlow A. A multi-country study of dengue vaccination strategies with Dengvaxia and a future vaccine candidate in three dengue-endemic countries: Vietnam, Thailand, and Colombia. VACCINE. 2018;36(17):2346–55. - PubMed
    1. Giersing BK, Karron RA, Vekemans J, Kaslow DC, Moorthy VS. Meeting report: WHO consultation on respiratory syncytial virus (RSV) vaccine development, Geneva, 25–26 April 2016. Vaccine. 2019;37(50):7355–62. - PubMed
    1. Saber Y, Philippe G, Assiri AM, Gessner BD, Badriah A. Prevention of meningococcal disease at mass gatherings: lessons from the hajj and Umrah. Vaccine. 2018;36(31):4603–9. - PubMed
    1. Adams LG, Khare S, Lawhon SD, Rossetti CA, Lewin HA, Lipton MS, et al. Enhancing the role of veterinary vaccines reducing zoonotic diseases of humans: linking systems biology with vaccine development. Vaccine. 2011;29(41):7197–206. - PMC - PubMed
    1. Kew NNOM. From emergence to eradication: the epidemiology of poliomyelitis deconstructed. Am J Epidemiol. 2010;172(11):1213–29. - PMC - PubMed

Publication types