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Review
. 2021 Jul;62(Suppl 2):51S-56S.
doi: 10.2967/jnumed.120.246033.

18F-6-Fluoro-l-Dopa PET/CT Imaging of Congenital Hyperinsulinism

Lisa J States  1   2 , J Christopher Davis  3   2 , Steven M Hamel  3 , Susan A Becker  3 , Hongming Zhuang  3   2
Affiliations
Free article
Review

18F-6-Fluoro-l-Dopa PET/CT Imaging of Congenital Hyperinsulinism

Lisa J States et al. J Nucl Med. 2021 Jul.
Free article

Abstract

Congenital hyperinsulinism is characterized by persistent hypoglycemia due to inappropriate excess secretion of insulin resulting in hyperinsulinemic hypoglycemia. The clinical course varies from mild to severe, with a significant risk for brain damage. Imaging plays a valuable role in the care of infants and children with severe hypoglycemia unresponsive to medical therapy. 18F-6-fluoro-l-dopa PET/CT is the method of choice for the detection and localization of a focal lesion of hyperinsulinism. Surgical resection of a focal lesion can lead to a cure with limited pancreatectomy. This article reviews the role of 18F-6-fluoro-l-dopa PET/CT in the management of this vulnerable population.

Trial registration: ClinicalTrials.gov NCT01916148.

Keywords: 18F-FDOPA; congenital hyperinsulinism; hyperinsulinism.

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