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. 2022 Jan;67(1):65-67.
doi: 10.1038/s10038-021-00958-2. Epub 2021 Jul 7.

Human genetic variant E756del in the ion channel PIEZO1 not associated with protection from severe malaria in a large Ghanaian study

Thorsten Thye  1 , Jennifer A Evans  2   3 , Gerd Ruge  4 , Wibke Loag  4 , Daniel Ansong  3 , Tsiri Agbenyega  5 , Rolf D Horstmann  2 , Jürgen May  4   6 , Kathrin Schuldt  4
Affiliations

Human genetic variant E756del in the ion channel PIEZO1 not associated with protection from severe malaria in a large Ghanaian study

Thorsten Thye et al. J Hum Genet. 2022 Jan.

Abstract

Recently, a common genetic variant E756del in the human gene PIEZO1 was associated with protection from severe malaria. Here, we performed a genetic association study of this gain-of-function variant in a large case-control study including 4149 children from the Ashanti Region in Ghana, West Africa. The statistical analysis did not indicate an association with protection from severe malaria and, thus, providing evidence against a strong protective effect of the PIEZO1 E756del variant on severe malaria susceptibility.

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Conflict of interest statement

The authors declare no competing interests.

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