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. 2021;75(11):5759-5772.
doi: 10.1007/s11696-021-01760-2. Epub 2021 Jul 2.

A garlic oil-based organo-hydrogel for use in pH-sensitive drug release

Duygu Alpaslan  1 , Tulü Olak  1 , Abdullah Turan  2 , Tuba Ersen Dudu  1 , Nahit Aktas  1   3
Affiliations

A garlic oil-based organo-hydrogel for use in pH-sensitive drug release

Duygu Alpaslan et al. Chem Zvesti. 2021.

Abstract

In this study, six different organo-hydrogels containing agar-glycerol (AG)-based garlic oil (GO) were synthesized using two different crosslinkers (N,N, methylenebisacrylamide (MBA), glutaraldehyde (GA)) to ensure the controlled release of ceftriaxone (Ce) and carboplatin (Cp). Synthesized organo-hydrogels were characterized by FT-IR. Afterward, swelling behaviors were investigated in DI, tap water, ethanol, acetone, ethanol/DI water (1:1), acetone/DI water (1:1) and gasoline environments and different pH. As a result of hemolysis, blood clotting and antioxidant analysis, organo-hydrogels have been shown to have blood compatibility and antioxidant properties. Ce and Cp release properties of the prepared organo-hydrogels were also determined. The highest Ce release rate was obtained to be 37.8% for p (AG-g-GO)3 at pH 8.0 after 7 days. However, the highest Cp release rate was found to be 95.4% for p (AG-g-GO)3 at pH 7.4 after 1 day.

Keywords: Agar; Carboplatin; Ceftriaxone; Garlic oil; Organo-hydrogel.

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Figures

Fig. 1
Fig. 1
Synthesis and schematic presentation of organo-hydrogels
Fig. 2
Fig. 2
Percent swelling degree of the a AG, p(AG-m), p(AG-g) and b organo-hydrogels with time in DI water, tap water, ethanol, acetone, ethanol/ID water (1:1), acetone/DI water (1:1) and gasoline. Swelling % of the c AG, p(AG-m), p(AG-g) and d organo-hydrogels as a function of 2–12 pH (pH is adjusted by the addition of 0.1 M HCl, 0.1 M NaOH)
Fig. 3
Fig. 3
FT-IR spectra of a AG, p(AG-m), and p(AG-m-GO)3, b AG, p(AG-g) and p(AG-g-GO)3 c drugs-loaded organo-hydrogels
Fig. 4
Fig. 4
Blood compatibility of the AG, p(AG-m), p(AG-g) and organo-hydrogels a hemolysis b blood clotting
Fig. 5
Fig. 5
Release behavior of ceftriaxone a 2.0 pHs b 5.5 pHs c 7.4 pHs d 8.0 pHs from organo-hydrogels and carboplatin e 7.4 pHs organo-hydrogels (The first 600 min of ceftriaxone and carboplatin release is given in the graph)
See this image and copyright information in PMC

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